Seroatlas · Human Serome Atlas

SERINC4

Serine incorporator 4

Also known as: FLJ40363, SERC4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NH21
Gene: SERINC4
Ensembl: ENSG00000184716
Chromosome: 15
Canonical length: 518 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in phospholipid biosynthetic process. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

518 residues, UniProt reviewed canonical sequence.

>A6NH21|SERINC4
     1  MVGAKAGPSP GTSLGLAQQH SGGSSVLVKS PFCQVCCCGP APCASCCHSR WPSLTASTCS
    61  RLFYILLHVG ASAICCLLLS RTVVERVWGK THRIQMPSGL CAHLFGLSDC PVLSGSGAVY
   121  RVCAGTATFH LLQAVLLVHL HSPTSPRAQL HNSFWLLKLL FLLGLCAIAF CIPDEHLFPA
   181  WHYIGICGGF AFILLQLVLI TAFAHSWNKN WQTGAAQDCS WFLAVLLATL GFYSMAGVGA
   241  VLLFHYYTHP AGCLLNKMLL SLHLCFCGLI SFLSIAPCIR LKQPRSGLLQ ASVISCYIMY
   301  LTFSALSSRP PERVILQGQN HTLCLPGLSK MEPQTPDISL AMLSASIMYA CVLFACNEAS
   361  YLAEVFGPLW IVKVYSYEFQ KPSLCFCCPE TVEADKGQRG GAARPADQET PPAPPVQVQH
   421  LSYNYSAFHF VFFLASLYVM VTLTNWFSYE GAELEKTFIK GSWATFWVKV ASCWACVLLY
   481  LGLLLAPLCW PPTQKPQPLI LRRRRHRIIS PDNKYPPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SERINC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

retina: 14 nTPM
choroid plexus: 3.4 nTPM
testis: 1.1 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
cerebellum: 0.1 nTPM

Single-cell type

cardiomyocytes: 20 nCPM
rod photoreceptor cells: 13 nCPM
choroid plexus epithelial cells: 12 nCPM
epicardial cells: 6.8 nCPM
retinal pigment epithelial cells: 4.3 nCPM
cone photoreceptor cells: 4.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 1.6 nTPM
thalamus: 0.5 nTPM
basal ganglia: 0.4 nTPM
hippocampal formation: 0.4 nTPM
amygdala: 0.3 nTPM
medulla oblongata: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
gnomAD missense Z: -0.44
DepMap mean gene effect: -0.27
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

phospholipid biosynthetic process

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SERINC4 as an antibody target. Whether an autoantibody or antibody against SERINC4 could matter depends on whether native SERINC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SERINC4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SERINC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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