Seroatlas · Human Serome Atlas

SERINC1

Serine incorporator 1

Also known as: KIAA1253, SERC1_HUMAN, TDE1L, TDE2, TMS-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NRX5
Gene
SERINC1
Ensembl
ENSG00000111897
Chromosome
6
Canonical length
453 aa
Protein class
Plasma proteins, Predicted membrane proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Predicted to enable acetyltransferase activator activity; enzyme binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in membrane biogenesis; phosphatidylserine metabolic process; and sphingolipid metabolic process. Predicted to be located in endoplasmic reticulum membrane and plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

453 residues, UniProt reviewed canonical sequence.

>Q9NRX5|SERINC1
     1  MGSVLGLCSM ASWIPCLCGS APCLLCRCCP SGNNSTVTRL IYALFLLVGV CVACVMLIPG
    61  MEEQLNKIPG FCENEKGVVP CNILVGYKAV YRLCFGLAMF YLLLSLLMIK VKSSSDPRAA
   121  VHNGFWFFKF AAAIAIIIGA FFIPEGTFTT VWFYVGMAGA FCFILIQLVL LIDFAHSWNE
   181  SWVEKMEEGN SRCWYAALLS ATALNYLLSL VAIVLFFVYY THPASCSENK AFISVNMLLC
   241  VGASVMSILP KIQESQPRSG LLQSSVITVY TMYLTWSAMT NEPETNCNPS LLSIIGYNTT
   301  STVPKEGQSV QWWHAQGIIG LILFLLCVFY SSIRTSNNSQ VNKLTLTSDE STLIEDGGAR
   361  SDGSLEDGDD VHRAVDNERD GVTYSYSFFH FMLFLASLYI MMTLTNWYRY EPSREMKSQW
   421  TAVWVKISSS WIGIVLYVWT LVAPLVLTNR DFD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SERINC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
10
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
451 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 451 nTPM
  • cerebral cortex: 348 nTPM
  • midbrain: 318 nTPM
  • hypothalamus: 253 nTPM
  • hippocampal formation: 240 nTPM
  • amygdala: 235 nTPM

Single-cell type

  • neutrophils: 603 nCPM
  • kupffer cells: 297 nCPM
  • monocytes: 204 nCPM
  • corticotrophs: 194 nCPM
  • lymphatic endothelial cells: 190 nCPM
  • retinal pigment epithelial cells: 179 nCPM

Immune cell

  • basophil: 159 nTPM
  • neutrophil: 109 nTPM
  • eosinophil: 93 nTPM
  • non-classical monocyte: 62 nTPM
  • total PBMC: 56 nTPM
  • T-reg: 54 nTPM

Brain region

  • white matter: 484 nTPM
  • pons: 437 nTPM
  • spinal cord: 414 nTPM
  • hypothalamus: 389 nTPM
  • medulla oblongata: 373 nTPM
  • midbrain: 364 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.61
gnomAD pLI
0.01
gnomAD missense Z
1.36
DepMap mean gene effect
0.21
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SERINC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SERINC1 as an antibody target. Whether an autoantibody or antibody against SERINC1 could matter depends on whether native SERINC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SERINC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SERINC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SERINC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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