Seroatlas · Human Serome Atlas

SERINC2

Serine incorporator 2

Also known as: FKSG84, PRO0899, SERC2_HUMAN, TDE2, TDE2L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96SA4
Gene: SERINC2
Ensembl: ENSG00000168528
Chromosome: 1
Canonical length: 455 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Enables phospholipid scramblase activity. Involved in plasma membrane phospholipid scrambling. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

455 residues, UniProt reviewed canonical sequence.

>Q96SA4|SERINC2
     1  MGACLGACSL LSCASCLCGS APCILCSCCP ASRNSTVSRL IFTFFLFLGV LVSIIMLSPG
    61  VESQLYKLPW VCEEGAGIPT VLQGHIDCGS LLGYRAVYRM CFATAAFFFF FTLLMLCVSS
   121  SRDPRAAIQN GFWFFKFLIL VGLTVGAFYI PDGSFTNIWF YFGVVGSFLF ILIQLVLLID
   181  FAHSWNQRWL GKAEECDSRA WYAGLFFFTL LFYLLSIAAV ALMFMYYTEP SGCHEGKVFI
   241  SLNLTFCVCV SIAAVLPKVQ DAQPNSGLLQ ASVITLYTMF VTWSALSSIP EQKCNPHLPT
   301  QLGNETVVAG PEGYETQWWD APSIVGLIIF LLCTLFISLR SSDHRQVNSL MQTEECPPML
   361  DATQQQQQVA ACEGRAFDNE QDGVTYSYSF FHFCLVLASL HVMMTLTNWY KPGETRKMIS
   421  TWTAVWVKIC ASWAGLLLYL WTLVAPLLLR NRDFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SERINC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 11
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 241 nTPM

Expression across tissuesHPA

Tissue

liver: 241 nTPM
salivary gland: 152 nTPM
esophagus: 124 nTPM
kidney: 115 nTPM
duodenum: 112 nTPM
urinary bladder: 109 nTPM

Single-cell type

esophageal apical cells: 1,119 nCPM
breast lactating cells: 888 nCPM
cytotrophoblasts: 594 nCPM
syncytiotrophoblasts: 496 nCPM
colonocytes: 494 nCPM
enterocytes: 408 nCPM

Immune cell

plasmacytoid DC: 10 nTPM
classical monocyte: 2.4 nTPM
eosinophil: 2.2 nTPM
intermediate monocyte: 0.7 nTPM
total PBMC: 0.6 nTPM
myeloid DC: 0.5 nTPM

Brain region

thalamus: 13 nTPM
choroid plexus: 5 nTPM
midbrain: 3.8 nTPM
pons: 3.2 nTPM
medulla oblongata: 3 nTPM
white matter: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: -0.26
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SERINC2 as an antibody target. Whether an autoantibody or antibody against SERINC2 could matter depends on whether native SERINC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SERINC2 is annotated at the cell surface, where native SERINC2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SERINC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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