Connector enhancer of kinase suppressor of Ras
IPR051566
Definition
The CNKSR family proteins function as adapter or scaffold proteins involved in various signaling pathways. They enhance guanine-nucleotide exchange on ARF6, regulate Ras signaling, and are implicated in cell migration and transepithelial sodium transport. The family members coordinate the assembly of protein complexes, such as the ENaC-regulatory complex (ERC), and are involved in the regulation of cell surface expression of channels like ENaC. Their roles are essential in processes like HGF-dependent activation of Arf6 and aldosterone-induced sodium transport, contributing to cellular responses to external stimuli and intracellular signaling.
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Loading the interactive Seroatlas explorer...