Seroatlas · Human Serome Atlas

CNK3/IPCEF1

CNK3/IPCEF1 fusion protein

Also known as: CNIPF_HUMAN, ENSG00000288520

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: G9CGD6
Gene: CNK3/IPCEF1
Ensembl: ENSG00000288520
Chromosome: 6
Canonical length: 899 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Nuclear speckles,Plasma membrane,Cytoplasmic bodies

OverviewNCBI Gene

No narrative summary is available for CNK3/IPCEF1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

899 residues, UniProt reviewed canonical sequence.

>G9CGD6|CNK3/IPCEF1
     1  MEPVTKWSPK QVVDWTRGLD DCLQQYVHKF EREKINGEQL LQISHQDLEE LGVTRIGHQE
    61  LVLEAVDLLC ALNYGLETDN MKNLVLKLRA SSHNLQNYIS SRRKSPAYDG NTSRKAPNEF
   121  LTSVVELIGA AKALLAWLDR APFTGITDFS VTKNKIIQLC LDLTTTVQKD CFVAEMEDKV
   181  LTVVKVLNGI CDKTIRSTTD PVMSQCACLE EVHLPNIKPG EGLGMYIKST YDGLHVITGT
   241  TENSPADRSQ KIHAGDEVIQ VNQQTVVGWQ LKNLVKKLRE NPTGVVLLLK KRPTGSFNFT
   301  PAPLKNLRWK PPLVQTSPPP ATTQSPESTM DTSLKKEKSA ILDLYIPPPP AVPYSPRDEN
   361  GSFVYGGSSK CKQPLPGPKG SESPNSFLDQ ESRRRRFTIA DSDQLPGYSV ETNILPTKMR
   421  EKTPSYGKPR PLSMPADGNW MGIVDPFARP RGHGRKAFVS TKMTSYMAID GSALVPLRQK
   481  PRRKTQGFLT MSRRRISCKD LGHADCQGWL YKKKEKGSFL SNKWKKFWVI LKGSSLYWYS
   541  NQMAEKADGF VNLPDFTVER ASECKKKHAF KISHPQIKTF YFAAENVQEM NVWLNKLGSA
   601  VIHQESTTKD EECYSESEQE DPEIAAETPP PPHASQTQSL TAQQASSSSP SLSGTSYSFS
   661  SLENTVKTPS SFPSSLSKER QSLPDTVNSL SAAEDEGQPI TFAVQVHSPV PSEAGIHKAL
   721  ENSFVTSESG FLNSLSSDDT SSLSSNHDHL TVPDKPAGSK IMDKEETKVS EDDEMEKLYK
   781  SLEQASLSPL GDRRPSTKKE LRKSFVKRCK NPSINEKLHK IRTLNSTLKC KEHDLAMINQ
   841  LLDDPKLTAR KYREWKVMNT LLIQDIYQQQ RASPAPDDTD DTPQELKKSP SSPSVENSI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNK3/IPCEF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 1.3 nTPM

Expression across tissuesHPA

Tissue

pancreas: 1.3 nTPM
esophagus: 0.9 nTPM
kidney: 0.9 nTPM
choroid plexus: 0.8 nTPM
endometrium: 0.7 nTPM
liver: 0.7 nTPM

Single-cell type

endometrial luminal cells: 61 nCPM
endometrial glandular cells: 35 nCPM
endometrial ciliated cells: 29 nCPM
epididymal clear cells: 29 nCPM
retinal pigment epithelial cells: 21 nCPM
myosatellite cells: 17 nCPM

Immune cell

eosinophil: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 2.2 nTPM
choroid plexus: 1.6 nTPM
cerebral cortex: 1.4 nTPM
medulla oblongata: 1.4 nTPM
cerebellum: 1.3 nTPM
pons: 1.3 nTPM

OntologyGO

Biological processes

regulation of signal transduction
positive regulation of cellular response to hepatocyte growth factor stimulus

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CNK3/IPCEF1 as an antibody target. Whether an autoantibody or antibody against CNK3/IPCEF1 could matter depends on whether native CNK3/IPCEF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CNK3/IPCEF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CNK3/IPCEF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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