Seroatlas · Human Serome Atlas

SHC2

SHC-transforming protein 2

Also known as: SCK, SHC2_HUMAN, SHCB, SLI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P98077
Gene: SHC2
Ensembl: ENSG00000129946
Chromosome: 19
Canonical length: 582 aa
Protein class: Predicted intracellular proteins, RAS pathway related proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be located in cytosol. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

582 residues, UniProt reviewed canonical sequence.

>P98077|SHC2
     1  MTQGPGGRAP PAPPAPPEPE APTTFCALLP RMPQWKFAAP GGFLGRGPAA ARAAGASGGA
    61  DPQPEPAGPG GVPALAAAVL GACEPRCAAP CPLPALSRCR GAGSRGSRGG RGAAGSGDAA
   121  AAAEWIRKGS FIHKPAHGWL HPDARVLGPG VSYVVRYMGC IEVLRSMRSL DFNTRTQVTR
   181  EAINRLHEAV PGVRGSWKKK APNKALASVL GKSNLRFAGM SISIHISTDG LSLSVPATRQ
   241  VIANHHMPSI SFASGGDTDM TDYVAYVAKD PINQRACHIL ECCEGLAQSI ISTVGQAFEL
   301  RFKQYLHSPP KVALPPERLA GPEESAWGDE EDSLEHNYYN SIPGKEPPLG GLVDSRLALT
   361  QPCALTALDQ GPSPSLRDAC SLPWDVGSTG TAPPGDGYVQ ADARGPPDHE EHLYVNTQGL
   421  DAPEPEDSPK KDLFDMRPFE DALKLHECSV AAGVTAAPLP LEDQWPSPPT RRAPVAPTEE
   481  QLRQEPWYHG RMSRRAAERM LRADGDFLVR DSVTNPGQYV LTGMHAGQPK HLLLVDPEGV
   541  VRTKDVLFES ISHLIDHHLQ NGQPIVAAES ELHLRGVVSR EP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SHC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 100 nTPM

Expression across tissuesHPA

Tissue

pancreas: 100 nTPM
liver: 57 nTPM
pituitary gland: 45 nTPM
hypothalamus: 34 nTPM
cerebral cortex: 33 nTPM
thyroid gland: 30 nTPM

Single-cell type

pancreatic acinar cells: 119 nCPM
oligodendrocyte progenitor cells: 77 nCPM
hepatocytes: 67 nCPM
lymphatic endothelial cells: 55 nCPM
salivary acinar cells: 49 nCPM
astrocytes: 49 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 69 nTPM
medulla oblongata: 55 nTPM
amygdala: 47 nTPM
thalamus: 46 nTPM
cerebral cortex: 45 nTPM
pons: 45 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.33
gnomAD pLI: 0
gnomAD missense Z: 0.27
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

receptor tyrosine kinase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SHC2 as an antibody target. Whether an autoantibody or antibody against SHC2 could matter depends on whether native SHC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SHC2 is annotated at the cell surface, where native SHC2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SHC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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