SHC3

Protein identityUniProt · HPA

UniProt accession

Q92529

Gene

SHC3

Ensembl

ENSG00000148082

Chromosome

9

Canonical length

594 aa

Protein class

Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

Enables phosphotyrosine residue binding activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within glutamatergic synaptic transmission and learning or memory. Predicted to be located in cytosol. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

594 residues, UniProt reviewed canonical sequence.

>Q92529|SHC3
     1  MLPRTKYNRF RNDSVTSVDD LLHSLSVSGG GGKVSAARAT PAAAPYLVSG EALRKAPDDG
    61  PGSLGHLLHK VSHLKLSSSG LRGLSSAARE RAGARLSGSC SAPSLAAPDG SAPSAPRAPA
   121  MSAARKGRPG DEPLPRPPRG APHASDQVLG PGVTYVVKYL GCIEVLRSMR SLDFSTRTQI
   181  TREAISRVCE AVPGAKGAFK KRKPPSKMLS SILGKSNLQF AGMSISLTIS TASLNLRTPD
   241  SKQIIANHHM RSISFASGGD PDTTDYVAYV AKDPVNRRAC HILECCDGLA QDVIGSIGQA
   301  FELRFKQYLQ CPTKIPALHD RMQSLDEPWT EEEGDGSDHP YYNSIPSKMP PPGGFLDTRL
   361  KPRPHAPDTA QFAGKEQTYY QGRHLGDTFG EDWQQTPLRQ GSSDIYSTPE GKLHVAPTGE
   421  APTYVNTQQI PPQAWPAAVS SAESSPRKDL FDMKPFEDAL KNQPLGPVLS KAASVECISP
   481  VSPRAPDAKM LEELQAETWY QGEMSRKEAE GLLEKDGDFL VRKSTTNPGS FVLTGMHNGQ
   541  AKHLLLVDPE GTIRTKDRVF DSISHLINHH LESSLPIVSA GSELCLQQPV ERKQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SHC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.52

Highest tissue expression

40 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.54

gnomAD pLI

0.05

gnomAD missense Z

1.4

DepMap mean gene effect

-0.22

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell surface receptor protein tyrosine kinase signaling pathway
• central nervous system development
• epidermal growth factor receptor signaling pathway
• intracellular signal transduction

Molecular functions

• phosphotyrosine residue binding
• receptor tyrosine kinase binding

Cellular components

• cytosol
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• SH2 domain
• Phosphotyrosine interaction domain, Shc-like
• PTB/PI domain
• PH-like domain superfamily
• SH2 adaptor protein C, SH2 domain
• SH2 domain superfamily
• Centrosomal Protein 152/SHC-Transforming Protein
• SH2 domain
• Phosphotyrosine interaction domain (PTB/PID)

KeywordsUniProt

• Phosphoprotein
• SH2 domain

InteractionsUniProt · HPA

Protein binding partners of SHC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ARHGAP32