SHC4

Protein identityUniProt · HPA

UniProt accession

Q6S5L8

Gene

SHC4

Ensembl

ENSG00000185634

Chromosome

15

Canonical length

630 aa

Protein class

Predicted intracellular proteins, RAS pathway related proteins

Subcellular location

Cytosol

OverviewNCBI Gene

Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within several processes, including apoptotic process; positive regulation of cell population proliferation; and stem cell differentiation. Predicted to be located in postsynaptic membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

630 residues, UniProt reviewed canonical sequence.

>Q6S5L8|SHC4
     1  MRERGQDSLA GLVLYVGLFG HPGMLHRAKY SRFRNESITS LDEGSSGGSV GNKGSPQPPH
    61  PALAPHLPTE DATLPSQESP TPLCTLIPRM ASMKLANPAT LLSLKNFCLG TKEVPRLKLQ
   121  ESRDPGSSGP SSPETSLSRS GTAPPPQQDL VGHRATALTP DSCPLPGPGE PTLRSRQDRH
   181  FLQHLLGMGM NYCVRYMGCV EVLQSMRSLD FGMRTQVTRE AISRLCEAVP GANGAIKKRK
   241  PPVKFLSTVL GKSNLQFSGM NIKLTISTCS LTLMNLDNQQ IIANHHMQSI SFASGGDPDT
   301  TDYVAYVAKD PVNQRACHIL ECHNGMAQDV ISTIGQAFEL RFKQYLKNPS LNTSCESEEV
   361  HIDSHAEERE DHEYYNEIPG KQPPVGGVSD MRIKVQATEQ MAYCPIQCEK LCYLPGNSKC
   421  SSVYENCLEQ SRAIGNVHPR GVQSQRDTSL LKHTCRVDLF DDPCYINTQA LQSTPGSAGN
   481  QRSAQPLGSP WHCGKAPETV QPGATAQPAS SHSLPHIKQQ LWSEECYHGK LSRKAAESLL
   541  VKDGDFLVRE SATSPGQYVL SGLQGGQAKH LLLVDPEGKV RTKDHVFDNV GHLIRYHMDN
   601  SLPIISSGSE VSLKQPVRKD NNPALLHSNK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SHC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.53

Highest tissue expression

15 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.94

gnomAD pLI

0

gnomAD missense Z

0.12

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• cell surface receptor protein tyrosine kinase signaling pathway
• intracellular signal transduction
• positive regulation of cell population proliferation
• regulation of gene expression
• stem cell differentiation

Molecular functions

• protein domain specific binding
• receptor tyrosine kinase binding

Cellular components

• plasma membrane
• postsynaptic membrane

Protein domainsUniProt · Pfam · InterPro

• SH2 domain
• Phosphotyrosine interaction domain, Shc-like
• PTB/PI domain
• PH-like domain superfamily
• SH2 adaptor protein C, SH2 domain
• SH2 domain superfamily
• Centrosomal Protein 152/SHC-Transforming Protein
• SH2 domain
• Phosphotyrosine interaction domain (PTB/PID)

KeywordsUniProt

• Cell membrane
• Membrane
• Phosphoprotein
• Postsynaptic cell membrane
• SH2 domain
• Synapse

InteractionsUniProt · HPA

Protein binding partners of SHC4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GRB2
• EGFR