Chondroitin sulfate glycosyltransferase
IPR051227
Definition
This family of proteins is involved in the biosynthesis of chondroitin sulfate, a key component of the extracellular matrix in cartilage. Members of this family exhibit glycosyltransferase activity, transferring glucuronic acid and N-acetylgalactosamine from their respective UDP-sugar donors to the growing chondroitin polymer. These enzymes play crucial roles in cartilage formation and endochondral ossification, a process where bone tissue is created. Some family members are also implicated in the metabolism of aggrecan, a major proteoglycan in cartilage, and in various developmental processes including cell division, cytokinesis, and neural development. Additionally, certain enzymes within this family are involved in the synthesis of N,N'-diacetyllactosediamine structures on glycoproteins, which are important for cell-cell interactions and signaling.
8 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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