Seroatlas · Human Serome Atlas

CHPF2

Chondroitin sulfate glucuronyltransferase

Also known as: CHPF2_HUMAN, ChSy-3, CSGlcA-T, KIAA1402

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P2E5
Gene: CHPF2
Ensembl: ENSG00000033100
Chromosome: 7
Canonical length: 772 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to enable glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

772 residues, UniProt reviewed canonical sequence.

>Q9P2E5|CHPF2
     1  MRLSSLLALL RPALPLILGL SLGCSLSLLR VSWIQGEGED PCVEAVGERG GPQNPDSRAR
    61  LDQSDEDFKP RIVPYYRDPN KPYKKVLRTR YIQTELGSRE RLLVAVLTSR ATLSTLAVAV
   121  NRTVAHHFPR LLYFTGQRGA RAPAGMQVVS HGDERPAWLM SETLRHLHTH FGADYDWFFI
   181  MQDDTYVQAP RLAALAGHLS INQDLYLGRA EEFIGAGEQA RYCHGGFGYL LSRSLLLRLR
   241  PHLDGCRGDI LSARPDEWLG RCLIDSLGVG CVSQHQGQQY RSFELAKNRD PEKEGSSAFL
   301  SAFAVHPVSE GTLMYRLHKR FSALELERAY SEIEQLQAQI RNLTVLTPEG EAGLSWPVGL
   361  PAPFTPHSRF EVLGWDYFTE QHTFSCADGA PKCPLQGASR ADVGDALETA LEQLNRRYQP
   421  RLRFQKQRLL NGYRRFDPAR GMEYTLDLLL ECVTQRGHRR ALARRVSLLR PLSRVEILPM
   481  PYVTEATRVQ LVLPLLVAEA AAAPAFLEAF AANVLEPREH ALLTLLLVYG PREGGRGAPD
   541  PFLGVKAAAA ELERRYPGTR LAWLAVRAEA PSQVRLMDVV SKKHPVDTLF FLTTVWTRPG
   601  PEVLNRCRMN AISGWQAFFP VHFQEFNPAL SPQRSPPGPP GAGPDPPSPP GADPSRGAPI
   661  GGRFDRQASA EGCFYNADYL AARARLAGEL AGQEEEEALE GLEVMDVFLR FSGLHLFRAV
   721  EPGLVQKFSL RDCSPRLSEE LYHRCRLSNL EGLGGRAQLA MALFEQEQAN ST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHPF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 38 nTPM
adrenal gland: 28 nTPM
blood vessel: 27 nTPM
bone marrow: 26 nTPM
spleen: 24 nTPM
pancreas: 22 nTPM

Single-cell type

cardiomyocytes: 129 nCPM
epicardial cells: 73 nCPM
breast lactating cells: 32 nCPM
plasma cells: 29 nCPM
extravillous trophoblasts: 25 nCPM
neutrophils: 23 nCPM

Immune cell

neutrophil: 7.3 nTPM
plasmacytoid DC: 7.1 nTPM
eosinophil: 6.4 nTPM
myeloid DC: 4.9 nTPM
classical monocyte: 4.4 nTPM
gdT-cell: 4 nTPM

Brain region

choroid plexus: 38 nTPM
hypothalamus: 32 nTPM
medulla oblongata: 31 nTPM
thalamus: 30 nTPM
pons: 29 nTPM
cerebral cortex: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0
gnomAD missense Z: -0.52
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

chondroitin sulfate proteoglycan biosynthetic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHPF2 as an antibody target. Whether an autoantibody or antibody against CHPF2 could matter depends on whether native CHPF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHPF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHPF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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