Seroatlas · Human Serome Atlas

CHSY3

Chondroitin sulfate synthase 3

Also known as: CHSS3_HUMAN, CHSY-2, CSS3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q70JA7
Gene
CHSY3
Ensembl
ENSG00000198108
Chromosome
5
Canonical length
882 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

CSS3 is a glycosyltransferase that has both glucuronyltransferase and N-acetylgalactosaminyltransferase activities (Yada et al., 2003 [PubMed 12907687]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

882 residues, UniProt reviewed canonical sequence.

>Q70JA7|CHSY3
     1  MAVRSRRPWM SVALGLVLGF TAASWLIAPR VAELSERKRR GSSLCSYYGR SAAGPRAGAQ
    61  QPLPQPQSRP RQEQSPPPAR QDLQGPPLPE AAPGITSFRS SPWQQPPPLQ QRRRGREPEG
   121  ATGLPGAPAA EGEPEEEDGG AAGQRRDGRP GSSHNGSGDG GAAAPSARPR DFLYVGVMTA
   181  QKYLGSRALA AQRTWARFIP GRVEFFSSQQ PPNAGQPPPP LPVIALPGVD DSYPPQKKSF
   241  MMIKYMHDHY LDKYEWFMRA DDDVYIKGDK LEEFLRSLNS SKPLYLGQTG LGNIEELGKL
   301  GLEPGENFCM GGPGMIFSRE VLRRMVPHIG ECLREMYTTH EDVEVGRCVR RFGGTQCVWS
   361  YEMQQLFHEN YEHNRKGYIQ DLHNSKIHAA ITLHPNKRPA YQYRLHNYML SRKISELRYR
   421  TIQLHRESAL MSKLSNTEVS KEDQQLGVIP SFNHFQPRER NEVIEWEFLT GKLLYSAAEN
   481  QPPRQSLSSI LRTALDDTVL QVMEMINENA KSRGRLIDFK EIQYGYRRVN PMHGVEYILD
   541  LLLLYKRHKG RKLTVPVRRH AYLQQLFSKP FFRETEELDV NSLVESINSE TQSFSFISNS
   601  LKILSSFQGA KEMGGHNEKK VHILVPLIGR YDIFLRFMEN FENMCLIPKQ NVKLVIILFS
   661  RDSGQDSSKH IELIKGYQNK YPKAEMTLIP MKGEFSRGLG LEMASAQFDN DTLLLFCDVD
   721  LIFREDFLQR CRDNTIQGQQ VYYPIIFSQY DPKVTNGGNP PTDDYFIFSK KTGFWRDYGY
   781  GITCIYKSDL LGAGGFDTSI QGWGLEDVDL YNKVILSGLR PFRSQEVGVV HIFHPVHCDP
   841  NLDPKQYKMC LGSKASTFAS TMQLAELWLE KHLGVRYNRT LS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHSY3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
10 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 10 nTPM
  • adipose tissue: 5.7 nTPM
  • cervix: 4.2 nTPM
  • breast: 2.7 nTPM
  • gallbladder: 2.6 nTPM
  • cerebral cortex: 2.1 nTPM

Single-cell type

  • endometrial stromal cells: 759 nCPM
  • brain excitatory neurons: 503 nCPM
  • brain inhibitory neurons: 480 nCPM
  • melanocytes: 412 nCPM
  • pericytes: 282 nCPM
  • microglia: 263 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 10 nTPM
  • hippocampal formation: 9.1 nTPM
  • basal ganglia: 8.7 nTPM
  • white matter: 6.3 nTPM
  • amygdala: 6.2 nTPM
  • thalamus: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.57
gnomAD pLI
0
gnomAD missense Z
0.84
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHSY3 as an antibody target. Whether an autoantibody or antibody against CHSY3 could matter depends on whether native CHSY3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHSY3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHSY3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHSY3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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