Seroatlas · Human Serome Atlas

CSGALNACT2

Chondroitin sulfate N-acetylgalactosaminyltransferase 2

Also known as: CGAT2_HUMAN, GALNACT-2, GALNACT2, MGC40204, PRO0082

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N6G5
Gene
CSGALNACT2
Ensembl
ENSG00000169826
Chromosome
10
Canonical length
542 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Endoplasmic reticulum

OverviewNCBI Gene

This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. The encoded protein is involved in elongation during chondroitin sulfate synthesis. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome X. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

542 residues, UniProt reviewed canonical sequence.

>Q8N6G5|CSGALNACT2
     1  MPRRGLILHT RTHWLLLGLA LLCSLVLFMY LLECAPQTDG NASLPGVVGE NYGKEYYQAL
    61  LQEQEEHYQT RATSLKRQIA QLKQELQEMS EKMRSLQERR NVGANGIGYQ SNKEQAPSDL
   121  LEFLHSQIDK AEVSIGAKLP SEYGVIPFES FTLMKVFQLE MGLTRHPEEK PVRKDKRDEL
   181  VEVIEAGLEV INNPDEDDEQ EDEEGPLGEK LIFNENDFVE GYYRTERDKG TQYELFFKKA
   241  DLTEYRHVTL FRPFGPLMKV KSEMIDITRS IINIIVPLAE RTEAFVQFMQ NFRDVCIHQD
   301  KKIHLTVVYF GKEGLSKVKS ILESVTSESN FHNYTLVSLN EEFNRGRGLN VGARAWDKGE
   361  VLMFFCDVDI YFSAEFLNSC RLNAEPGKKV FYPVVFSLYN PAIVYANQEV PPPVEQQLVH
   421  KKDSGFWRDF GFGMTCQYRS DFLTIGGFDM EVKGWGGEDV HLYRKYLHGD LIVIRTPVPG
   481  LFHLWHEKRC ADELTPEQYR MCIQSKAMNE ASHSHLGMLV FREEIETHLH KQAYRTNSEA
   541  VG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CSGALNACT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
127 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 127 nTPM
  • thymus: 26 nTPM
  • lung: 25 nTPM
  • spleen: 25 nTPM
  • placenta: 25 nTPM
  • gallbladder: 24 nTPM

Single-cell type

  • neutrophils: 2,076 nCPM
  • neutrophil progenitors: 1,283 nCPM
  • monocytes: 581 nCPM
  • monocyte progenitors: 425 nCPM
  • cdc: 243 nCPM
  • macrophages: 223 nCPM

Immune cell

  • non-classical monocyte: 22 nTPM
  • eosinophil: 19 nTPM
  • basophil: 15 nTPM
  • myeloid DC: 14 nTPM
  • intermediate monocyte: 14 nTPM
  • classical monocyte: 12 nTPM

Brain region

  • cerebellum: 33 nTPM
  • cerebral cortex: 30 nTPM
  • white matter: 30 nTPM
  • choroid plexus: 29 nTPM
  • medulla oblongata: 25 nTPM
  • hypothalamus: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.48
gnomAD pLI
0.24
gnomAD missense Z
1.12
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CSGALNACT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CSGALNACT2 as an antibody target. Whether an autoantibody or antibody against CSGALNACT2 could matter depends on whether native CSGALNACT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CSGALNACT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CSGALNACT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CSGALNACT2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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