Seroatlas · Human Serome Atlas

SLC1A7

Excitatory amino acid transporter 5

Also known as: EAA5_HUMAN, EAAT5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00341
Gene: SLC1A7
Ensembl: ENSG00000162383
Chromosome: 1
Canonical length: 560 aa
Protein class: Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Enables glutamate:sodium symporter activity. Involved in neurotransmitter uptake. Predicted to be located in photoreceptor cell terminal bouton. Predicted to be active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

560 residues, UniProt reviewed canonical sequence.

>O00341|SLC1A7
     1  MVPHAILARG RDVCRRNGLL ILSVLSVIVG CLLGFFLRTR RLSPQEISYF QFPGELLMRM
    61  LKMMILPLVV SSLMSGLASL DAKTSSRLGV LTVAYYLWTT FMAVIVGIFM VSIIHPGSAA
   121  QKETTEQSGK PIMSSADALL DLIRNMFPAN LVEATFKQYR TKTTPVVKSP KVAPEEAPPR
   181  RILIYGVQEE NGSHVQNFAL DLTPPPEVVY KSEPGTSDGM NVLGIVFFSA TMGIMLGRMG
   241  DSGAPLVSFC QCLNESVMKI VAVAVWYFPF GIVFLIAGKI LEMDDPRAVG KKLGFYSVTV
   301  VCGLVLHGLF ILPLLYFFIT KKNPIVFIRG ILQALLIALA TSSSSATLPI TFKCLLENNH
   361  IDRRIARFVL PVGATINMDG TALYEAVAAI FIAQVNNYEL DFGQIITISI TATAASIGAA
   421  GIPQAGLVTM VIVLTSVGLP TDDITLIIAV DWALDRFRTM INVLGDALAA GIMAHICRKD
   481  FARDTGTEKL LPCETKPVSL QEIVAAQQNG CVKSVAEASE LTLGPTCPHH VPVQVEQDEE
   541  LPAASLNHCT IQISELETNV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC1A7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

retina: 37 nTPM
gallbladder: 4.9 nTPM
small intestine: 2.9 nTPM
tongue: 2.8 nTPM
ovary: 2.5 nTPM
duodenum: 2.2 nTPM

Single-cell type

retinal bipolar cells: 379 nCPM
rod photoreceptor cells: 147 nCPM
cone photoreceptor cells: 126 nCPM
fibro-adipogenic progenitors: 61 nCPM
epicardial cells: 46 nCPM
enterocytes: 20 nCPM

Immune cell

gdT-cell: 2.2 nTPM
naive CD8 T-cell: 0.9 nTPM
memory CD8 T-cell: 0.8 nTPM
total PBMC: 0.3 nTPM
naive CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM

Brain region

thalamus: 3.8 nTPM
midbrain: 3.1 nTPM
pons: 2.7 nTPM
medulla oblongata: 2.2 nTPM
amygdala: 2.1 nTPM
spinal cord: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0
gnomAD missense Z: 0.07
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC1A7 as an antibody target. Whether an autoantibody or antibody against SLC1A7 could matter depends on whether native SLC1A7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC1A7 is annotated at the cell surface, where native SLC1A7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC1A7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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