Ankyrin Repeat and SOCS Box

Definition

The Ankyrin Repeat and SOCS Box (ASB) family proteins are involved in a variety of cellular processes, including transcription regulation, ubiquitination, and proteasomal degradation of target proteins. They often act as substrate-recognition components of E3 ubiquitin-protein ligase complexes, which are part of the ubiquitin-proteasome system responsible for protein turnover. Some family members function as transcription factors interacting with purine-rich repeats, while others may play roles in the immune response or cell cycle regulation. The ankyrin repeats typically mediate protein-protein interactions, and the SOCS box domain is crucial for binding to the Elongin BC complex, an adapter in E3 ligase complexes.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• ANKRD23
• ANKRD61
• ASB10
• GABPB1
• GABPB2