Seroatlas · Human Serome Atlas

ANKRD61

Ankyrin repeat domain-containing protein 61

Also known as: ANR61_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NGH8
Gene: ANKRD61
Ensembl: ENSG00000157999
Chromosome: 7
Canonical length: 418 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

418 residues, UniProt reviewed canonical sequence.

>A6NGH8|ANKRD61
     1  MGNITRKGSR DLVVDSAKSL EDGPSAALHS KLYEAIMRED CTTIEVLLRN HPVNQPITIL
    61  PNSASNRLLL TQPTESIIPI HLAAKYHKAQ SLLCLLRHGA DPEVRDTTGL TTLNLMLLHW
   121  PVTSTTWAKP GNRTHRILTD IQNSSITCLR ILCAHGAQVN TQGEISNKRS PLHLAIAYGC
   181  YPVLSILTQN GADVNAINEA SMTPLHMAAN MLNKEMMETL IAYGANVNCA VSSTGNTPLK
   241  LAVCTASSKA GRLLGAGVSC IRLLLTHGAK VNAQDYKGQT AIHEACFGGR EAIINLLLEF
   301  EANVNILTRN GESPIYMYLQ RSCNVRDTAL LARLLYHTYP LRMTNNQGIL PAGIMLPEFR
   361  LLRDTLIKQS QKPLSLQGIC KRNIRNIYGE KYKQHLKQFL PVTIWNSVYC CYDLAYTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD61 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 5.7 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 5.7 nTPM
testis: 5.6 nTPM
skin: 1.2 nTPM
lymph node: 0.7 nTPM
retina: 0.7 nTPM
pancreas: 0.6 nTPM

Single-cell type

early spermatids: 66 nCPM
late primary spermatocytes: 42 nCPM
late spermatids: 34 nCPM
cardiomyocytes: 12 nCPM
epicardial cells: 4.5 nCPM
sertoli cells: 4.5 nCPM

Immune cell

myeloid DC: 0.2 nTPM
basophil: 0.1 nTPM
classical monocyte: 0.1 nTPM
intermediate monocyte: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
eosinophil: 0 nTPM

Brain region

cerebellum: 5.4 nTPM
white matter: 5.2 nTPM
choroid plexus: 4.7 nTPM
pons: 4.2 nTPM
thalamus: 4 nTPM
cerebral cortex: 3.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0
gnomAD missense Z: 1.34
DepMap mean gene effect: 0.1
DepMap dependency class: none

OntologyGO

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD61 as an antibody target. Whether an autoantibody or antibody against ANKRD61 could matter depends on whether native ANKRD61 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD61 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD61 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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