Seroatlas · Human Serome Atlas

ANKRD23

Ankyrin repeat domain-containing protein 23

Also known as: ANR23_HUMAN, DARP, FLJ32449, MARP3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86SG2
Gene: ANKRD23
Ensembl: ENSG00000163126
Chromosome: 2
Canonical length: 305 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Actin filaments,Cytosol

OverviewNCBI Gene

This gene is a member of the muscle ankyrin repeat protein (MARP) family and encodes a protein with four tandem ankyrin-like repeats. The protein is localized to the nucleus, functioning as a transcriptional regulator. Expression of this protein is induced during recovery following starvation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

305 residues, UniProt reviewed canonical sequence.

>Q86SG2|ANKRD23
     1  MDFISIQQLV SGERVEGKVL GFGHGVPDPG AWPSDWRRGP QEAVAREKLK LEEEKKKKLE
    61  RFNSTRFNLD NLADLENLVQ RRKKRLRHRV PPRKPEPLVK PQSQAQVEPV GLEMFLKAAA
   121  ENQEYLIDKY LTDGGDPNAH DKLHRTALHW ACLKGHSQLV NKLLVAGATV DARDLLDRTP
   181  VFWACRGGHL VILKQLLNQG ARVNARDKIG STPLHVAVRT RHPDCLEHLI ECGAHLNAQD
   241  KEGDTALHEA VRHGSYKAMK LLLLYGAELG VRNAASVTPV QLARDWQRGI REALQAHVAH
   301  PRTRC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 1,348 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 1,348 nTPM
tongue: 419 nTPM
heart muscle: 23 nTPM
salivary gland: 19 nTPM
pituitary gland: 9.8 nTPM
esophagus: 5.7 nTPM

Single-cell type

myonuclei: 473 nCPM
thymic myoid cells: 174 nCPM
respiratory ciliated cells: 80 nCPM
somatotrophs: 79 nCPM
thyrotrophs: 77 nCPM
rod photoreceptor cells: 76 nCPM

Immune cell

gdT-cell: 0.1 nTPM
NK-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

medulla oblongata: 4.7 nTPM
white matter: 4.2 nTPM
cerebellum: 4 nTPM
basal ganglia: 3.8 nTPM
cerebral cortex: 3.8 nTPM
thalamus: 3.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0
gnomAD missense Z: 0.58
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANKRD23 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD23 as an antibody target. Whether an autoantibody or antibody against ANKRD23 could matter depends on whether native ANKRD23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD23 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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