Seroatlas · Human Serome Atlas

LAMP5

Lysosome-associated membrane glycoprotein 5

Also known as: BAD-LAMP, C20orf103, dJ1119D9.3, LAMP5_HUMAN, UNC-46

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UJQ1
Gene: LAMP5
Ensembl: ENSG00000125869
Chromosome: 20
Canonical length: 280 aa
Protein class: Predicted membrane proteins
Subcellular location: Mitotic spindle,Centriolar satellite,Cytosol

OverviewNCBI Gene

Predicted to be involved in establishment of protein localization to organelle. Located in endoplasmic reticulum-Golgi intermediate compartment membrane; endosome membrane; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

280 residues, UniProt reviewed canonical sequence.

>Q9UJQ1|LAMP5
     1  MDLQGRGVPS IDRLRVLLML FHTMAQIMAE QEVENLSGLS TNPEKDIFVV RENGTTCLMA
    61  EFAAKFIVPY DVWASNYVDL ITEQADIALT RGAEVKGRCG HSQSELQVFW VDRAYALKML
   121  FVKESHNMSK GPEATWRLSK VQFVYDSSEK THFKDAVSAG KHTANSHHLS ALVTPAGKSY
   181  ECQAQQTISL ASSDPQKTVT MILSAVHIQP FDIISDFVFS EEHKCPVDER EQLEETLPLI
   241  LGLILGLVIM VTLAIYHVHH KMTANQVQIP RDRSQYKHMG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LAMP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 298 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 298 nTPM
amygdala: 55 nTPM
cerebral cortex: 41 nTPM
ovary: 38 nTPM
hippocampal formation: 38 nTPM
retina: 27 nTPM

Single-cell type

pdcs: 216 nCPM
granulosa cells: 143 nCPM
bergmann glia: 92 nCPM
brain inhibitory neurons: 73 nCPM
ovarian stromal cells: 65 nCPM
retinal horizontal cells: 36 nCPM

Immune cell

plasmacytoid DC: 142 nTPM
myeloid DC: 9.5 nTPM
memory B-cell: 4.5 nTPM
basophil: 4.3 nTPM
total PBMC: 2.4 nTPM
classical monocyte: 1.7 nTPM

Brain region

basal ganglia: 198 nTPM
cerebral cortex: 105 nTPM
pons: 96 nTPM
medulla oblongata: 85 nTPM
amygdala: 82 nTPM
hippocampal formation: 78 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.61
gnomAD pLI: 0
gnomAD missense Z: -0.2
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LAMP5 as an antibody target. Whether an autoantibody or antibody against LAMP5 could matter depends on whether native LAMP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LAMP5 is annotated at the cell surface, where native LAMP5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LAMP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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