Seroatlas · Human Serome Atlas

LAMP3

Lysosome-associated membrane glycoprotein 3

Also known as: CD208, DC-LAMP, DCLAMP, LAMP, LAMP3_HUMAN, TSC403

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UQV4
Gene: LAMP3
Ensembl: ENSG00000078081
Chromosome: 3
Canonical length: 416 aa
Protein class: CD markers, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Dendritic cells (DCs) are the most potent antigen-presenting cells. Immature DCs efficiently capture antigens and differentiate into interdigitating dendritic cells (IDCs) in lymphoid tissues that induce primary T-cell responses (summary by de Saint-Vis et al., 1998 [PubMed 9768752]).[supplied by OMIM, Dec 2010]

Canonical amino-acid sequenceUniProt

416 residues, UniProt reviewed canonical sequence.

>Q9UQV4|LAMP3
     1  MPRQLSAAAA LFASLAVILH DGSQMRAKAF PETRDYSQPT AAATVQDIKK PVQQPAKQAP
    61  HQTLAARFMD GHITFQTAAT VKIPTTTPAT TKNTATTSPI TYTLVTTQAT PNNSHTAPPV
   121  TEVTVGPSLA PYSLPPTITP PAHTTGTSSS TVSHTTGNTT QPSNQTTLPA TLSIALHKST
   181  TGQKPVQPTH APGTTAAAHN TTRTAAPAST VPGPTLAPQP SSVKTGIYQV LNGSRLCIKA
   241  EMGIQLIVQD KESVFSPRRY FNIDPNATQA SGNCGTRKSN LLLNFQGGFV NLTFTKDEES
   301  YYISEVGAYL TVSDPETIYQ GIKHAVVMFQ TAVGHSFKCV SEQSLQLSAH LQVKTTDVQL
   361  QAFDFEDDHF GNVDECSSDY TIVLPVIGAI VVGLCLMGMG VYKIRLRCQS SGYQRI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LAMP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 207 nTPM

Expression across tissuesHPA

Tissue

lung: 207 nTPM
appendix: 31 nTPM
thymus: 26 nTPM
salivary gland: 26 nTPM
testis: 21 nTPM
tonsil: 20 nTPM

Single-cell type

alveolar cells type 2: 926 nCPM
transitional alveolar cells: 189 nCPM
late spermatids: 144 nCPM
cdc: 105 nCPM
late primary spermatocytes: 80 nCPM
epididymal basal cells: 66 nCPM

Immune cell

eosinophil: 5.6 nTPM
T-reg: 4.8 nTPM
MAIT T-cell: 2.4 nTPM
naive CD4 T-cell: 2.3 nTPM
memory CD4 T-cell: 1.8 nTPM
naive CD8 T-cell: 1.3 nTPM

Brain region

cerebral cortex: 2.2 nTPM
hippocampal formation: 1.8 nTPM
medulla oblongata: 1.8 nTPM
cerebellum: 1.7 nTPM
hypothalamus: 1.7 nTPM
pons: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0
gnomAD missense Z: 0.28
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LAMP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

FURIN

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LAMP3 as an antibody target. Whether an autoantibody or antibody against LAMP3 could matter depends on whether native LAMP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LAMP3 is annotated at the cell surface, where native LAMP3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LAMP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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