Glucose transporter GLUT

Definition

This entry includes Class I and II glucose transporters. Facilitative sugar transport is mediated by members of the GLUT transporter family, which form an aqueous pore across the membrane through which sugars can move in a passive (i.e., energy-independent) manner. The GLUT family of glycosylated transmembrane proteins are predicted to span the membrane 12 times with both amino- and carboxyl-termini located in the cytosol. On the basis of sequence homology and structural similarity, three subclasses of sugar transporters have been defined: Class I (GLUTs 1-4) are glucose transporters; Class II (GLUTs 5, 7, 9 and 11) are fructose transporters; and Class III (GLUTs 6, 8, 10, 12 and HMIT1) are structurally atypical members of the GLUT family, which are poorly defined at present, indeed GLUT6 may only be a pseudo-gene [[cite:PMID:2180146], [cite:PMID:8366068], [cite:PMID:3839598], [cite:PMID:3170580], [cite:PMID:9841639]].

9 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (9 proteins: gene, accession, name)

• SLC2A1
• SLC2A11
• SLC2A14
• SLC2A2
• SLC2A3
• SLC2A4
• SLC2A5
• SLC2A7
• SLC2A9