Seroatlas · Human Serome Atlas

SLC2A5

Solute carrier family 2, facilitated glucose transporter member 5

Also known as: GLUT5, GTR5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P22732
Gene
SLC2A5
Ensembl
ENSG00000142583
Chromosome
1
Canonical length
501 aa
Protein class
Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane,Mid piece,Principal piece

OverviewNCBI Gene

The protein encoded by this gene is a fructose transporter responsible for fructose uptake by the small intestine. The encoded protein also is necessary for the increase in blood pressure due to high dietary fructose consumption. [provided by RefSeq, Jun 2016]

Canonical amino-acid sequenceUniProt

501 residues, UniProt reviewed canonical sequence.

>P22732|SLC2A5
     1  MEQQDQSMKE GRLTLVLALA TLIAAFGSSF QYGYNVAAVN SPALLMQQFY NETYYGRTGE
    61  FMEDFPLTLL WSVTVSMFPF GGFIGSLLVG PLVNKFGRKG ALLFNNIFSI VPAILMGCSR
   121  VATSFELIII SRLLVGICAG VSSNVVPMYL GELAPKNLRG ALGVVPQLFI TVGILVAQIF
   181  GLRNLLANVD GWPILLGLTG VPAALQLLLL PFFPESPRYL LIQKKDEAAA KKALQTLRGW
   241  DSVDREVAEI RQEDEAEKAA GFISVLKLFR MRSLRWQLLS IIVLMGGQQL SGVNAIYYYA
   301  DQIYLSAGVP EEHVQYVTAG TGAVNVVMTF CAVFVVELLG RRLLLLLGFS ICLIACCVLT
   361  AALALQDTVS WMPYISIVCV ISYVIGHALG PSPIPALLIT EIFLQSSRPS AFMVGGSVHW
   421  LSNFTVGLIF PFIQEGLGPY SFIVFAVICL LTTIYIFLIV PETKAKTFIE INQIFTKMNK
   481  VSEVYPEKEE LKELPPVTSE Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC2A5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
103 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 103 nTPM
  • bone marrow: 92 nTPM
  • small intestine: 80 nTPM
  • skeletal muscle: 74 nTPM
  • testis: 71 nTPM
  • tongue: 62 nTPM

Single-cell type

  • enterocytes: 212 nCPM
  • microglia: 179 nCPM
  • late primary spermatocytes: 158 nCPM
  • neutrophil progenitors: 80 nCPM
  • early spermatids: 51 nCPM
  • hematopoietic stem cells: 49 nCPM

Immune cell

  • naive B-cell: 23 nTPM
  • basophil: 4.9 nTPM
  • memory B-cell: 4.3 nTPM
  • classical monocyte: 2.5 nTPM
  • neutrophil: 1.5 nTPM
  • total PBMC: 1.2 nTPM

Brain region

  • medulla oblongata: 52 nTPM
  • white matter: 41 nTPM
  • thalamus: 34 nTPM
  • pons: 32 nTPM
  • spinal cord: 30 nTPM
  • cerebral cortex: 29 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC2A5.

Disease | ImmuneIEDB

Conditions an epitope on SLC2A5 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.19
gnomAD pLI
0
gnomAD missense Z
1.54
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC2A5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC2A5 as an antibody target. Whether an autoantibody or antibody against SLC2A5 could matter depends on whether native SLC2A5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC2A5 is annotated at the cell surface, where native SLC2A5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC2A5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC2A5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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