Seroatlas · Human Serome Atlas

SLC2A7

Solute carrier family 2, facilitated glucose transporter member 7

Also known as: GLUT7, GTR7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PXP3
Gene: SLC2A7
Ensembl: ENSG00000197241
Chromosome: 1
Canonical length: 512 aa
Protein class: Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

SLC2A7 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Li et al., 2004). This family of transporters shows conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

512 residues, UniProt reviewed canonical sequence.

>Q6PXP3|SLC2A7
     1  MENKEAGTPP PIPSREGRLQ PTLLLATLSA AFGSAFQYGY NLSVVNTPHK VFKSFYNETY
    61  FERHATFMDG KLMLLLWSCT VSMFPLGGLL GSLLVGLLVD SCGRKGTLLI NNIFAIIPAI
   121  LMGVSKVAKA FELIVFSRVV LGVCAGISYS ALPMYLGELA PKNLRGMVGT MTEVFVIVGV
   181  FLAQIFSLQA ILGNPAGWPV LLALTGVPAL LQLLTLPFFP ESPRYSLIQK GDEATARQAL
   241  RRLRGHTDME AELEDMRAEA RAERAEGHLS VLHLCALRSL RWQLLSIIVL MAGQQLSGIN
   301  AINYYADTIY TSAGVEAAHS QYVTVGSGVV NIVMTITSAV LVERLGRRHL LLAGYGICGS
   361  ACLVLTVVLL FQNRVPELSY LGIICVFAYI AGHSIGPSPV PSVVRTEIFL QSSRRAAFMV
   421  DGAVHWLTNF IIGFLFPSIQ EAIGAYSFII FAGICLLTAI YIYVVIPETK GKTFVEINRI
   481  FAKRNRVKLP EEKEETIDAG PPTASPAKET SF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC2A7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 2.3 nTPM

Expression across tissuesHPA

Tissue

duodenum: 2.3 nTPM
small intestine: 2.2 nTPM
epididymis: 0.3 nTPM
testis: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

plasma cells: 5.9 nCPM
granulosa cells: 5.7 nCPM
enterocytes: 4.7 nCPM
undifferentiated spermatogonia: 3.9 nCPM
epididymal principal cells: 2.4 nCPM
epicardial cells: 2.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.67
gnomAD pLI: 0
gnomAD missense Z: -0.02
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 0% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC2A7 as an antibody target. Whether an autoantibody or antibody against SLC2A7 could matter depends on whether native SLC2A7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC2A7 is annotated at the cell surface, where native SLC2A7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC2A7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...