Seroatlas · Human Serome Atlas

SLC2A11

Solute carrier family 2, facilitated glucose transporter member 11

Also known as: GLUT11, GTR11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BYW1
Gene: SLC2A11
Ensembl: ENSG00000133460
Chromosome: 22
Canonical length: 496 aa
Protein class: Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Cell Junctions

OverviewNCBI Gene

This gene belongs to a family of proteins that mediate the transport of sugars across the cell membrane. The encoded protein transports glucose and fructose. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Canonical amino-acid sequenceUniProt

496 residues, UniProt reviewed canonical sequence.

>Q9BYW1|SLC2A11
     1  MRALRRLIQG RILLLTICAA GIGGTFQFGY NLSIINAPTL HIQEFTNETW QARTGEPLPD
    61  HLVLLMWSLI VSLYPLGGLF GALLAGPLAI TLGRKKSLLV NNIFVVSAAI LFGFSRKAGS
   121  FEMIMLGRLL VGVNAGVSMN IQPMYLGESA PKELRGAVAM SSAIFTALGI VMGQVVGLRE
   181  LLGGPQAWPL LLASCLVPGA LQLASLPLLP ESPRYLLIDC GDTEACLAAL RRLRGSGDLA
   241  GELEELEEER AACQGCRARR PWELFQHRAL RRQVTSLVVL GSAMELCGND SVYAYASSVF
   301  RKAGVPEAKI QYAIIGTGSC ELLTAVVSCV VIERVGRRVL LIGGYSLMTC WGSIFTVALC
   361  LQSSFPWTLY LAMACIFAFI LSFGIGPAGV TGILATELFD QMARPAACMV CGALMWIMLI
   421  LVGLGFPFIM EALSHFLYVP FLGVCVCGAI YTGLFLPETK GKTFQEISKE LHRLNFPRRA
   481  QGPTWRSLEV IQSTEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC2A11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

retina: 23 nTPM
cerebellum: 21 nTPM
kidney: 17 nTPM
pituitary gland: 14 nTPM
pancreas: 14 nTPM
basal ganglia: 13 nTPM

Single-cell type

platelets: 24 nCPM
late spermatids: 14 nCPM
pancreatic acinar cells: 9.5 nCPM
rod photoreceptor cells: 8.2 nCPM
decidual stromal cells: 8 nCPM
breast myoepithelial cells: 7.7 nCPM

Immune cell

plasmacytoid DC: 2.4 nTPM
memory B-cell: 1.2 nTPM
naive B-cell: 1.1 nTPM
naive CD4 T-cell: 1 nTPM
naive CD8 T-cell: 0.7 nTPM
basophil: 0.6 nTPM

Brain region

cerebellum: 15 nTPM
hypothalamus: 14 nTPM
midbrain: 14 nTPM
pons: 13 nTPM
cerebral cortex: 13 nTPM
choroid plexus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.32
gnomAD pLI: 0
gnomAD missense Z: 0.52
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC2A11 as an antibody target. Whether an autoantibody or antibody against SLC2A11 could matter depends on whether native SLC2A11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC2A11 is annotated at the cell surface, where native SLC2A11 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC2A11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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