Seroatlas · Human Serome Atlas

SLC2A14

Solute carrier family 2, facilitated glucose transporter member 14

Also known as: GLUT14, GTR14_HUMAN, SLC2A3P3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TDB8
Gene
SLC2A14
Ensembl
ENSG00000173262
Chromosome
12
Canonical length
520 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane

OverviewNCBI Gene

Members of the glucose transporter (GLUT) family, including SLC2A14, are highly conserved integral membrane proteins that transport hexoses such as glucose and fructose into all mammalian cells. GLUTs show tissue and cell-type specific expression (Wu and Freeze, 2002 [PubMed 12504846]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

520 residues, UniProt reviewed canonical sequence.

>Q8TDB8|SLC2A14
     1  MEFHNGGHVS GIGGFLVSLT SRMKPHTLAV TPALIFAITV ATIGSFQFGY NTGVINAPET
    61  IIKEFINKTL TDKANAPPSE VLLTNLWSLS VAIFSVGGMI GSFSVGLFVN RFGRRNSMLI
   121  VNLLAATGGC LMGLCKIAES VEMLILGRLV IGLFCGLCTG FVPMYIGEIS PTALRGAFGT
   181  LNQLGIVIGI LVAQIFGLEL ILGSEELWPV LLGFTILPAI LQSAALPCCP ESPRFLLINR
   241  KKEENATRIL QRLWGTQDVS QDIQEMKDES ARMSQEKQVT VLELFRVSSY RQPIIISIVL
   301  QLSQQLSGIN AVFYYSTGIF KDAGVQQPIY ATISAGVVNT IFTLLSLFLV ERAGRRTLHM
   361  IGLGGMAFCS TLMTVSLLLK NHYNGMSFVC IGAILVFVAC FEIGPGPIPW FIVAELFSQG
   421  PRPAAMAVAG CSNWTSNFLV GLLFPSAAYY LGAYVFIIFT GFLITFLAFT FFKVPETRGR
   481  TFEDITRAFE GQAHGADRSG KDGVMGMNSI EPAKETTTNV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC2A14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
76 nTPM

Expression across tissuesHPA

Tissue

  • testis: 76 nTPM
  • pancreas: 6.2 nTPM
  • bone marrow: 5.9 nTPM
  • adrenal gland: 5.1 nTPM
  • liver: 2.6 nTPM
  • ovary: 2.6 nTPM

Single-cell type

  • pancreatic acinar cells: 109 nCPM
  • late primary spermatocytes: 103 nCPM
  • adrenal cortex cells: 89 nCPM
  • early primary spermatocytes: 64 nCPM
  • granulosa cells: 62 nCPM
  • erythrocyte progenitors: 46 nCPM

Immune cell

  • basophil: 3.7 nTPM
  • neutrophil: 3.3 nTPM
  • eosinophil: 1 nTPM
  • T-reg: 1 nTPM
  • NK-cell: 0.7 nTPM
  • MAIT T-cell: 0.6 nTPM

Brain region

  • cerebellum: 16 nTPM
  • choroid plexus: 10 nTPM
  • hippocampal formation: 9.3 nTPM
  • hypothalamus: 9 nTPM
  • cerebral cortex: 8.3 nTPM
  • basal ganglia: 7.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.6
gnomAD pLI
0.04
gnomAD missense Z
1.32
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC2A14 as an antibody target. Whether an autoantibody or antibody against SLC2A14 could matter depends on whether native SLC2A14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC2A14 is annotated at the cell surface, where native SLC2A14 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC2A14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC2A14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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