Seroatlas · Human Serome Atlas

SLC2A3

Solute carrier family 2, facilitated glucose transporter member 3

Also known as: GLUT3, GTR3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P11169
Gene
SLC2A3
Ensembl
ENSG00000059804
Chromosome
12
Canonical length
496 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane

OverviewNCBI Gene

Enables D-glucose binding activity; dehydroascorbic acid transmembrane transporter activity; and hexose transmembrane transporter activity. Involved in D-glucose import across plasma membrane; galactose transmembrane transport; and transport across blood-brain barrier. Located in aggresome and plasma membrane. Biomarker of Alzheimer's disease; acanthosis nigricans; diabetes mellitus; and type 2 diabetes mellitus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

496 residues, UniProt reviewed canonical sequence.

>P11169|SLC2A3
     1  MGTQKVTPAL IFAITVATIG SFQFGYNTGV INAPEKIIKE FINKTLTDKG NAPPSEVLLT
    61  SLWSLSVAIF SVGGMIGSFS VGLFVNRFGR RNSMLIVNLL AVTGGCFMGL CKVAKSVEML
   121  ILGRLVIGLF CGLCTGFVPM YIGEISPTAL RGAFGTLNQL GIVVGILVAQ IFGLEFILGS
   181  EELWPLLLGF TILPAILQSA ALPFCPESPR FLLINRKEEE NAKQILQRLW GTQDVSQDIQ
   241  EMKDESARMS QEKQVTVLEL FRVSSYRQPI IISIVLQLSQ QLSGINAVFY YSTGIFKDAG
   301  VQEPIYATIG AGVVNTIFTV VSLFLVERAG RRTLHMIGLG GMAFCSTLMT VSLLLKDNYN
   361  GMSFVCIGAI LVFVAFFEIG PGPIPWFIVA ELFSQGPRPA AMAVAGCSNW TSNFLVGLLF
   421  PSAAHYLGAY VFIIFTGFLI TFLAFTFFKV PETRGRTFED ITRAFEGQAH GADRSGKDGV
   481  MEMNSIEPAK ETTTNV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC2A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
404 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 404 nTPM
  • adipose tissue: 122 nTPM
  • placenta: 97 nTPM
  • urinary bladder: 92 nTPM
  • lung: 91 nTPM
  • retina: 81 nTPM

Single-cell type

  • neutrophils: 2,917 nCPM
  • monocytes: 1,084 nCPM
  • vascular endothelial cells: 769 nCPM
  • extravillous trophoblasts: 654 nCPM
  • platelets: 623 nCPM
  • mast cells: 611 nCPM

Immune cell

  • neutrophil: 225 nTPM
  • basophil: 167 nTPM
  • eosinophil: 30 nTPM
  • gdT-cell: 25 nTPM
  • T-reg: 25 nTPM
  • MAIT T-cell: 20 nTPM

Brain region

  • cerebral cortex: 69 nTPM
  • pons: 60 nTPM
  • hippocampal formation: 60 nTPM
  • hypothalamus: 57 nTPM
  • thalamus: 57 nTPM
  • medulla oblongata: 52 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.65
gnomAD pLI
0.01
gnomAD missense Z
1.03
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC2A3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC2A3 as an antibody target. Whether an autoantibody or antibody against SLC2A3 could matter depends on whether native SLC2A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC2A3 is annotated at the cell surface, where native SLC2A3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC2A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC2A3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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