Beta-thymosin superfamily

Definition

This entry represents beta-thymosin superfamily. Its members include thymosin beta-4, -10, -15 from humans and their homologues (such as thymosin beta 11/12) from fish. Thymosin beta-4 (Tbeta) is a small protein that sequesters actin monomers to help maintain the high concentrations of unpolymerised actin in higher eukaryotic cells. Its structure has been resolved PMID:25313062. It is a multiple function protein that plays important roles in cellular processes such as wound healing, embryonic organ development and the pathogeneses of disease [[cite:PMID:24993983], [cite:PMID:24732964]]. It plays a role in anti-apoptotic response to an external stress PMID:15037574, paclitaxel-resistance via ROS production [[cite:PMID:18306930], [cite:PMID:20637781]] and HIF-1alpha stabilisation via Erk activation PMID:18272284. It also regulates cancer cell migration through various signalling pathways, and hence plays a role in malignant progression and invasion in colon adenocarcinoma [[cite:PMID:22328534], [cite:PMID:12761500]].

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• TMSB10
• TMSB15A
• TMSB15B
• TMSB15C
• TMSB4X
• TMSB4Y