Seroatlas · Human Serome Atlas

TMSB4Y

Thymosin beta-4, Y-chromosomal

Also known as: TB4Y, TYB4Y_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14604
Gene
TMSB4Y
Ensembl
ENSG00000154620
Chromosome
Y
Canonical length
44 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene lies within the male specific region of chromosome Y. Its homolog on chromosome X escapes X inactivation and encodes an actin sequestering protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

44 residues, UniProt reviewed canonical sequence.

>O14604|TMSB4Y
     1  MSDKPGMAEI EKFDKSKLKK TETQEKNPLS SKETIEQERQ AGES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMSB4Y can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
6.2 nTPM

Expression across tissuesHPA

Tissue

  • rectum: 6.2 nTPM
  • prostate: 3.8 nTPM
  • spinal cord: 3.7 nTPM
  • testis: 3.6 nTPM
  • hypothalamus: 3.3 nTPM
  • epididymis: 3.2 nTPM

Single-cell type

  • podocytes: 1.5 nCPM
  • distal convoluted tubule cells: 1.3 nCPM
  • renal connecting tubule cells: 1.3 nCPM
  • loop of henle epithelial cells: 0.9 nCPM
  • renal collecting duct principal cells: 0.9 nCPM
  • thymocytes: 0.8 nCPM

Immune cell

  • myeloid DC: 3 nTPM
  • memory CD4 T-cell: 1.6 nTPM
  • total PBMC: 1.6 nTPM
  • classical monocyte: 1.5 nTPM
  • gdT-cell: 1.4 nTPM
  • intermediate monocyte: 1.3 nTPM

Brain region

  • medulla oblongata: 4.5 nTPM
  • pons: 4 nTPM
  • white matter: 4 nTPM
  • hypothalamus: 3.4 nTPM
  • basal ganglia: 3.3 nTPM
  • thalamus: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.86
gnomAD pLI
0.32
gnomAD missense Z
-0.5

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMSB4Y as an antibody target. Whether an autoantibody or antibody against TMSB4Y could matter depends on whether native TMSB4Y is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMSB4Y is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMSB4Y as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMSB4Y. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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