Seroatlas · Human Serome Atlas

TMSB10

Thymosin beta-10

Also known as: TB10, TYB10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P63313
Gene: TMSB10
Ensembl: ENSG00000034510
Chromosome: 2
Canonical length: 44 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable actin monomer binding activity. Predicted to be involved in regulation of cell migration. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

44 residues, UniProt reviewed canonical sequence.

>P63313|TMSB10
     1  MADKPDMGEI ASFDKAKLKK TETQEKNTLP TKETIEQEKR SEIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMSB10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 4,897 nTPM

Expression across tissuesHPA

Tissue

ovary: 4,897 nTPM
thymus: 3,614 nTPM
epididymis: 3,365 nTPM
lymph node: 3,073 nTPM
lung: 2,965 nTPM
colon: 2,898 nTPM

Single-cell type

extravillous trophoblasts: 17,494 nCPM
esophageal apical cells: 13,891 nCPM
kupffer cells: 11,216 nCPM
epididymal principal cells: 9,412 nCPM
esophageal suprabasal cells: 9,192 nCPM
enteric transient amplifying cells: 9,113 nCPM

Immune cell

total PBMC: 49,899 nTPM
T-reg: 24,250 nTPM
myeloid DC: 19,881 nTPM
classical monocyte: 18,299 nTPM
naive B-cell: 16,662 nTPM
memory B-cell: 16,260 nTPM

Brain region

cerebral cortex: 1,317 nTPM
basal ganglia: 1,050 nTPM
hypothalamus: 973 nTPM
white matter: 917 nTPM
thalamus: 889 nTPM
amygdala: 832 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TMSB10.

Disease | ImmuneIEDB

Conditions an epitope on TMSB10 was assayed in.

pancreatic ductal adenocarcinoma T cell
skin melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0.02
gnomAD missense Z: 0.91
DepMap mean gene effect: -0.45
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoskeleton

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMSB10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ACTB

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMSB10 as an antibody target. Whether an autoantibody or antibody against TMSB10 could matter depends on whether native TMSB10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMSB10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMSB10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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