Seroatlas · Human Serome Atlas

TMSB15A

Thymosin beta-15A

Also known as: TB15A_HUMAN, TMSL8, TMSNB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0CG34
Gene
TMSB15A
Ensembl
ENSG00000158164
Chromosome
X
Canonical length
45 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable actin monomer binding activity. Involved in positive regulation of cell migration. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

45 residues, UniProt reviewed canonical sequence.

>P0CG34|TMSB15A
     1  MSDKPDLSEV EKFDRSKLKK TNTEEKNTLP SKETIQQEKE CVQTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMSB15A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 16 nTPM
  • prostate: 15 nTPM
  • thymus: 12 nTPM
  • lung: 7.3 nTPM
  • thyroid gland: 5.5 nTPM
  • breast: 4.7 nTPM

Single-cell type

  • megakaryocytes: 74 nCPM
  • oocytes: 74 nCPM
  • granulosa cells: 24 nCPM
  • megakaryocyte progenitors: 22 nCPM
  • differentiating spermatogonia: 20 nCPM
  • undifferentiated spermatogonia: 18 nCPM

Immune cell

  • NK-cell: 0.5 nTPM
  • plasmacytoid DC: 0.2 nTPM
  • total PBMC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • cerebellum: 2.5 nTPM
  • choroid plexus: 1.8 nTPM
  • pons: 1.8 nTPM
  • cerebral cortex: 1.7 nTPM
  • hypothalamus: 1.5 nTPM
  • basal ganglia: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.73
gnomAD pLI
0.39
gnomAD missense Z
-0.13
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMSB15A as an antibody target. Whether an autoantibody or antibody against TMSB15A could matter depends on whether native TMSB15A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMSB15A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMSB15A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMSB15A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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