Seroatlas · Human Serome Atlas

TMSB15B

Thymosin beta-15B

Also known as: MGC39900, TB15B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0CG35
Gene
TMSB15B
Ensembl
ENSG00000158427
Chromosome
X
Canonical length
45 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable actin monomer binding activity. Involved in positive regulation of cell migration. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

45 residues, UniProt reviewed canonical sequence.

>P0CG35|TMSB15B
     1  MSDKPDLSEV EKFDRSKLKK TNTEEKNTLP SKETIQQEKE CVQTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMSB15B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 16 nTPM
  • blood vessel: 15 nTPM
  • cervix: 12 nTPM
  • endometrium: 10 nTPM
  • cerebellum: 7.7 nTPM
  • vagina: 7.5 nTPM

Single-cell type

  • sertoli cells: 13 nCPM
  • pancreatic islet cells: 11 nCPM
  • gonadotrophs: 8.7 nCPM
  • platelets: 7 nCPM
  • thymocytes: 6.8 nCPM
  • megakaryocyte-erythroid progenitors: 4.1 nCPM

Immune cell

  • memory B-cell: 6.4 nTPM
  • plasmacytoid DC: 6.2 nTPM
  • naive B-cell: 6 nTPM
  • T-reg: 5.2 nTPM
  • naive CD4 T-cell: 3.8 nTPM
  • NK-cell: 3.1 nTPM

Brain region

  • cerebellum: 18 nTPM
  • hypothalamus: 8.4 nTPM
  • cerebral cortex: 7.9 nTPM
  • midbrain: 7.4 nTPM
  • basal ganglia: 7.1 nTPM
  • pons: 6.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.73
gnomAD pLI
0.39
gnomAD missense Z
-0.72

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMSB15B as an antibody target. Whether an autoantibody or antibody against TMSB15B could matter depends on whether native TMSB15B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMSB15B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMSB15B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMSB15B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...