Ephrin-A ectodomain

Definition

Ephrins and their receptors EphR play an important role in cell communication in normal physiology, as well as in disease pathogenesis [[cite:PMID:18394988], [cite:PMID:15561600]]. Binding of the ephrin (Eph) ligand to EphR requires cell-cell contact, since both molecules are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling, depending on Eph kinase activity) and ephrin-expressing cells (reverse signaling) [[cite:PMID:18394988], [cite:PMID:12479863], [cite:PMID:18281458]]. Eph signaling controls cell morphology, adhesion, migration and invasion. Ephrins can be subdivided into two groups, A and B, depending on their respective receptors EphA or EphB. The nine human EphA receptors bind to five GPI-linked ephrin-A ligands PMID:12495863. Interactions are promiscuous within each class, and some Eph receptors can also bind to ephrins of the other class. All ephrin As contain a highly conserved receptor binding ectodomain described by this entry. Although ephrin As do not have a cytoplasmic tail (in contrast to ephrin Bs), they are still capable of downstream activation of Src family kinases and phosphoinositide-3-kinases, most likely involving co-receptors such as neurotrophin receptors [[cite:PMID:18593733], [cite:PMID:24003208]].

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• EFNA1
• EFNA2
• EFNA3
• EFNA4
• EFNA5