Seroatlas · Human Serome Atlas

EFNA2

Ephrin-A2

Also known as: EFNA2_HUMAN, ELF-1, EPLG6, LERK6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43921
Gene
EFNA2
Ensembl
ENSG00000099617
Chromosome
19
Canonical length
213 aa
Protein class
Cancer-related genes, Predicted intracellular proteins, RAS pathway related proteins
Subcellular location
Mitochondria,Cytosol
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

213 residues, UniProt reviewed canonical sequence.

>O43921|EFNA2
     1  MAPAQRPLLP LLLLLLPLPP PPFARAEDAA RANSDRYAVY WNRSNPRFHA GAGDDGGGYT
    61  VEVSINDYLD IYCPHYGAPL PPAERMEHYV LYMVNGEGHA SCDHRQRGFK RWECNRPAAP
   121  GGPLKFSEKF QLFTPFSLGF EFRPGHEYYY ISATPPNAVD RPCLRLKVYV RPTNETLYEA
   181  PEPIFTSNNS CSSPGGCRLF LSTIPVLWTL LGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EFNA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • liver: 13 nTPM
  • small intestine: 12 nTPM
  • duodenum: 9.4 nTPM
  • colon: 8.6 nTPM
  • rectum: 4.1 nTPM
  • gallbladder: 3.3 nTPM

Single-cell type

  • colonocytes: 68 nCPM
  • enterocytes: 60 nCPM
  • breast myoepithelial cells: 49 nCPM
  • enteric transient amplifying cells: 39 nCPM
  • epididymal basal cells: 36 nCPM
  • enteric stem cells: 29 nCPM

Immune cell

  • basophil: 0.5 nTPM
  • neutrophil: 0.2 nTPM
  • eosinophil: 0.1 nTPM
  • intermediate monocyte: 0.1 nTPM
  • MAIT T-cell: 0.1 nTPM
  • myeloid DC: 0.1 nTPM

Brain region

  • midbrain: 7.4 nTPM
  • thalamus: 7.4 nTPM
  • hypothalamus: 5.1 nTPM
  • spinal cord: 4.9 nTPM
  • amygdala: 4.3 nTPM
  • basal ganglia: 4.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.19
gnomAD pLI
0.04
gnomAD missense Z
1.25
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EFNA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EFNA2 as an antibody target. Whether an autoantibody or antibody against EFNA2 could matter depends on whether native EFNA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EFNA2 is annotated at the cell surface, where native EFNA2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label EFNA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EFNA2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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