Seroatlas · Human Serome Atlas

EFNA3

Ephrin-A3

Also known as: EFNA3_HUMAN, Ehk1-L, EPLG3, LERK3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P52797
Gene: EFNA3
Ensembl: ENSG00000143590
Chromosome: 1
Canonical length: 238 aa
Protein class: Predicted membrane proteins, RAS pathway related proteins

OverviewNCBI Gene

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

238 residues, UniProt reviewed canonical sequence.

>P52797|EFNA3
     1  MAAAPLLLLL LLVPVPLLPL LAQGPGGALG NRHAVYWNSS NQHLRREGYT VQVNVNDYLD
    61  IYCPHYNSSG VGPGAGPGPG GGAEQYVLYM VSRNGYRTCN ASQGFKRWEC NRPHAPHSPI
   121  KFSEKFQRYS AFSLGYEFHA GHEYYYISTP THNLHWKCLR MKVFVCCAST SHSGEKPVPT
   181  LPQFTMGPNV KINVLEDFEG ENPQVPKLEK SISGTSPKRE HLPLAVGIAF FLMTFLAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EFNA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 95 nTPM

Expression across tissuesHPA

Tissue

skin: 95 nTPM
esophagus: 29 nTPM
vagina: 26 nTPM
basal ganglia: 24 nTPM
cerebral cortex: 21 nTPM
cervix: 17 nTPM

Single-cell type

esophageal apical cells: 133 nCPM
esophageal suprabasal cells: 119 nCPM
oocytes: 97 nCPM
suprabasal keratinocytes: 85 nCPM
basal keratinocytes: 48 nCPM
extravillous trophoblasts: 44 nCPM

Immune cell

NK-cell: 2.7 nTPM
T-reg: 1.6 nTPM
myeloid DC: 1.4 nTPM
naive B-cell: 1.2 nTPM
plasmacytoid DC: 1.1 nTPM
memory B-cell: 1 nTPM

Brain region

cerebral cortex: 41 nTPM
hippocampal formation: 29 nTPM
white matter: 24 nTPM
basal ganglia: 23 nTPM
pons: 20 nTPM
amygdala: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.76
gnomAD pLI: 0.15
gnomAD missense Z: 0.67
DepMap mean gene effect: -0.32
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EFNA3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

EPHA8

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EFNA3 as an antibody target. Whether an autoantibody or antibody against EFNA3 could matter depends on whether native EFNA3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EFNA3 is annotated at the cell surface, where native EFNA3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label EFNA3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...