Seroatlas · Human Serome Atlas

OCEL1

Occludin/ELL domain-containing protein 1

Also known as: FLJ22709, OCEL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H607
Gene: OCEL1
Ensembl: ENSG00000099330
Chromosome: 19
Canonical length: 264 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Predicted to be involved in bicellular tight junction assembly. Predicted to be located in membrane. Predicted to be active in apical plasma membrane; bicellular tight junction; and cytoplasmic vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

264 residues, UniProt reviewed canonical sequence.

>Q9H607|OCEL1
     1  MHNPDGSASP TADPGSELQT LGQAARRPPP PRAGHDAPRR TRPSARKPLS CFSRRPMPTR
    61  EPPKTRGSRG HLHTHPPGPG PPLQGLAPRG LKTSAPRPPC QPQPGPHKAK TKKIVFEDEL
   121  LSQALLGAKK PIGAIPKGHK PRPHPVPDYE LKYPPVSSER ERSRYVAVFQ DQYGEFLELQ
   181  HEVGCAQAKL RQLEALLSSL PPPQSQKEAQ VAARVWREFE MKRMDPGFLD KQARCHYLKG
   241  KLRHLKTQIQ KFDDQGDSEG SVYF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OCEL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 76 nTPM

Expression across tissuesHPA

Tissue

liver: 76 nTPM
kidney: 40 nTPM
pancreas: 22 nTPM
adrenal gland: 21 nTPM
prostate: 21 nTPM
stomach: 21 nTPM

Single-cell type

syncytiotrophoblasts: 137 nCPM
fallopian tube ciliated cells: 127 nCPM
enterocytes: 125 nCPM
hepatocytes: 107 nCPM
respiratory ciliated cells: 80 nCPM
epididymal efferent duct ciliated cells: 79 nCPM

Immune cell

classical monocyte: 31 nTPM
basophil: 28 nTPM
myeloid DC: 23 nTPM
intermediate monocyte: 21 nTPM
T-reg: 19 nTPM
non-classical monocyte: 17 nTPM

Brain region

cerebral cortex: 18 nTPM
medulla oblongata: 15 nTPM
pons: 15 nTPM
thalamus: 14 nTPM
spinal cord: 14 nTPM
midbrain: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.16
gnomAD pLI: 0
gnomAD missense Z: -0.34
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

bicellular tight junction assembly

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OCEL1 as an antibody target. Whether an autoantibody or antibody against OCEL1 could matter depends on whether native OCEL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OCEL1 is annotated at the cell surface, where native OCEL1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OCEL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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