Seroatlas · Human Serome Atlas

ELL2

RNA polymerase II elongation factor ELL2

Also known as: ELL2_HUMAN, MRCCAT1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00472
Gene: ELL2
Ensembl: ENSG00000118985
Chromosome: 5
Canonical length: 640 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable cis-regulatory region sequence-specific DNA binding activity. Involved in snRNA transcription by RNA polymerase II. Located in nucleoplasm. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

640 residues, UniProt reviewed canonical sequence.

>O00472|ELL2
     1  MAAGGTGGLR EEQRYGLSCG RLGQDNITVL HVKLTETAIR ALETYQSHKN LIPFRPSIQF
    61  QGLHGLVKIP KNDPLNEVHN FNFYLSNVGK DNPQGSFDCI QQTFSSSGAS QLNCLGFIQD
   121  KITVCATNDS YQMTRERMTQ AEEESRNRST KVIKPGGPYV GKRVQIRKAP QAVSDTVPER
   181  KRSTPMNPAN TIRKTHSSST ISQRPYRDRV IHLLALKAYK KPELLARLQK DGVNQKDKNS
   241  LGAILQQVAN LNSKDLSYTL KDYVFKELQR DWPGYSEIDR RSLESVLSRK LNPSQNAAGT
   301  SRSESPVCSS RDAVSSPQKR LLDSEFIDPL MNKKARISHL TNRVPPTLNG HLNPTSEKSA
   361  AGLPLPPAAA AIPTPPPLPS TYLPISHPPQ IVNSNSNSPS TPEGRGTQDL PVDSFSQNDS
   421  IYEDQQDKYT SRTSLETLPP GSVLLKCPKP MEENHSMSHK KSKKKSKKHK EKDQIKKHDI
   481  ETIEEKEEDL KREEEIAKLN NSSPNSSGGV KEDCTASMEP SAIELPDYLI KYIAIVSYEQ
   541  RQNYKDDFNA EYDEYRALHA RMETVARRFI KLDAQRKRLS PGSKEYQNVH EEVLQEYQKI
   601  KQSSPNYHEE KYRCEYLHNK LAHIKRLIGE FDQQQAESWS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ELL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 96 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 96 nTPM
salivary gland: 91 nTPM
pancreas: 89 nTPM
liver: 81 nTPM
esophagus: 60 nTPM
skin: 56 nTPM

Single-cell type

neutrophils: 5,148 nCPM
mast cells: 2,268 nCPM
plasma cells: 1,499 nCPM
monocytes: 1,492 nCPM
pancreatic acinar cells: 1,448 nCPM
salivary acinar cells: 1,376 nCPM

Immune cell

basophil: 7 nTPM
eosinophil: 5.7 nTPM
memory B-cell: 3.5 nTPM
neutrophil: 1.8 nTPM
naive B-cell: 1.7 nTPM
NK-cell: 1.6 nTPM

Brain region

white matter: 128 nTPM
medulla oblongata: 124 nTPM
thalamus: 107 nTPM
hypothalamus: 84 nTPM
basal ganglia: 81 nTPM
pons: 79 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 1
gnomAD missense Z: 1.55
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cis-regulatory region sequence-specific DNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ELL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ELL2 as an antibody target. Whether an autoantibody or antibody against ELL2 could matter depends on whether native ELL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ELL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ELL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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