ELL3

Protein identityUniProt · HPA

UniProt accession

Q9HB65

Gene

ELL3

Ensembl

ENSG00000128886

Chromosome

15

Canonical length

397 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli,Mitotic chromosome

OverviewNCBI Gene

Predicted to enable cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of DNA-templated transcription and transcription by RNA polymerase II. Located in several cellular components, including chromosome; cytosol; and nuclear lumen. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

397 residues, UniProt reviewed canonical sequence.

>Q9HB65|ELL3
     1  MEELQEPLRG QLRLCFTQAA RTSLLLLRLN DAALRALQEC QRQQVRPVIA FQGHRGYLRL
    61  PGPGWSCLFS FIVSQCCQEG AGGSLDLVCQ RFLRSGPNSL HCLGSLRERL IIWAAMDSIP
   121  APSSVQGHNL TEDARHPESW QNTGGYSEGD AVSQPQMALE EVSVSDPLAS NQGQSLPGSS
   181  REHMAQWEVR SQTHVPNREP VQALPSSASR KRLDKKRSVP VATVELEEKR FRTLPLVPSP
   241  LQGLTNQDLQ EGEDWEQEDE DMDPRLEHSS SVQEDSESPS PEDIPDYLLQ YRAIHSAEQQ
   301  HAYEQDFETD YAEYRILHAR VGTASQRFIE LGAEIKRVRR GTPEYKVLED KIIQEYKKFR
   361  KQYPSYREEK RRCEYLHQKL SHIKGLILEF EEKNRGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ELL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.52

Highest tissue expression

54 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.16

gnomAD pLI

0

gnomAD missense Z

0.47

DepMap mean gene effect

-0.07

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• DNA-templated transcription elongation
• intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
• negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
• neural precursor cell proliferation
• positive regulation of DNA-templated transcription, elongation
• positive regulation of neural precursor cell proliferation
• positive regulation of neurogenesis
• positive regulation of stem cell proliferation
• positive regulation of transcription by RNA polymerase II
• positive regulation of transcription elongation by RNA polymerase II
• regulation of epithelial to mesenchymal transition
• snRNA transcription by RNA polymerase II
• spermatogenesis
• stem cell differentiation
• stem cell proliferation
• transcription by RNA polymerase II
• transcription elongation by RNA polymerase II

Molecular functions

• cis-regulatory region sequence-specific DNA binding

Cellular components

• cell junction
• chromosome
• cytosol
• nuclear speck
• nucleolus
• nucleoplasm
• nucleus
• transcription elongation factor complex

Protein domainsUniProt · Pfam · InterPro

• Occludin homology domain
• RNA polymerase II elongation factor ELL, N-terminal
• ELL/occludin family
• Occludin homology domain
• RNA polymerase II elongation factor ELL

KeywordsUniProt

• Nucleus
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of ELL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• AFF4
• EAF1