Pentaxin, conserved site

Definition

Pentaxins (or pentraxins) [[cite:PMID:6356809], [cite:PMID:7772283]] are a family of proteins which show, under electron microscopy, a discoid arrangement of five noncovalently bound subunits. Proteins known to belong to this family are: C-reactive protein (CRP), a protein which, in mammals, is expressed during acute phase response to tissue injury or inflammation. CRP displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. CRPs have also been sequenced in an invertebrate, the Atlantic horseshoe crab, where they are a normal constituent of the hemolymph. Serum Amyloid P-component (SAP), a precursor of amyloid component P which is found in basement membrane and is associated with amyloid deposits. Hamster female protein (FP), a plasma protein whose concentration is altered by sex steroids and stimuli that elicit an acute phase response. A number of proteins, whose function is not yet clear, contain a C-terminal pentaxin-like domain. These proteins are: Human PTX3 (or TSG-14). PTX3 is a cytokine-induced protein. Guinea pig apexin PMID:7798266, a sperm acrosomal protein. Apexin seems to be the ortholog of human neuronal pentraxin II (gene NPTX2) PMID:8530029. Rat neuronal pentaxin I PMID:7695898. The sequences of the different members of this family are quite conserved. This entry represents a six residue pattern which includes a cysteine known to be involved in a disulfide bridge in CRPs and SAP.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• APCS
• CRP
• NPTX1
• NPTX2
• PTX3