Seroatlas · Human Serome Atlas

NPTX2

Neuronal pentraxin-2

Also known as: NPTX2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P47972
Gene
NPTX2
Ensembl
ENSG00000106236
Chromosome
7
Canonical length
431 aa
Protein class
Predicted secreted proteins
Subcellular location
Golgi apparatus,Actin filaments,Centrosome
Secretome location
Secreted to blood
Quaternary structure
Homooligomer

OverviewNCBI Gene

This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD. [provided by RefSeq, Feb 2009]

Canonical amino-acid sequenceUniProt

431 residues, UniProt reviewed canonical sequence.

>P47972|NPTX2
     1  MLALLAASVA LAVAAGAQDS PAPGSRFVCT ALPPEAVHAG CPLPAMPMQG GAQSPEEELR
    61  AAVLQLRETV VQQKETLGAQ REAIRELTGK LARCEGLAGG KARGAGATGK DTMGDLPRDP
   121  GHVVEQLSRS LQTLKDRLES LEHQLRANVS NAGLPGDFRE VLQQRLGELE RQLLRKVAEL
   181  EDEKSLLHNE TSAHRQKTES TLNALLQRVT ELERGNSAFK SPDAFKVSLP LRTNYLYGKI
   241  KKTLPELYAF TICLWLRSSA SPGIGTPFSY AVPGQANEIV LIEWGNNPIE LLINDKVAQL
   301  PLFVSDGKWH HICVTWTTRD GMWEAFQDGE KLGTGENLAP WHPIKPGGVL ILGQEQDTVG
   361  GRFDATQAFV GELSQFNIWD RVLRAQEIVN IANCSTNMPG NIIPWVDNNV DVFGGASKWP
   421  VETCEERLLD L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPTX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
200 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 200 nTPM
  • cerebral cortex: 45 nTPM
  • adrenal gland: 39 nTPM
  • testis: 33 nTPM
  • hypothalamus: 30 nTPM
  • blood vessel: 29 nTPM

Single-cell type

  • corticotrophs: 336 nCPM
  • peritubular myoid cells: 304 nCPM
  • myosatellite cells: 224 nCPM
  • early primary spermatocytes: 166 nCPM
  • schwann cells: 164 nCPM
  • pancreatic acinar cells: 119 nCPM

Immune cell

  • plasmacytoid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 280 nTPM
  • hypothalamus: 106 nTPM
  • hippocampal formation: 81 nTPM
  • thalamus: 51 nTPM
  • white matter: 35 nTPM
  • pons: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.73
gnomAD pLI
0.03
gnomAD missense Z
0.68
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NPTX2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPTX2 as an antibody target. Whether an autoantibody or antibody against NPTX2 could matter depends on whether native NPTX2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPTX2 is annotated as secreted, so native NPTX2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NPTX2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NPTX2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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