CRP

Protein identityUniProt · HPA

UniProt accession

P02741

Gene

CRP

Ensembl

ENSG00000132693

Chromosome

1

Canonical length

224 aa

Protein class

Cancer-related genes, Candidate cardiovascular disease genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Subcellular location

Nucleoplasm,Vesicles,Intermediate filaments

Secretome location

Secreted to blood

Quaternary structure

Homopentamer

OverviewNCBI Gene

The protein encoded by this gene belongs to the pentraxin family which also includes serum amyloid P component protein and pentraxin 3. Pentraxins are involved in complement activation and amplification via communication with complement initiation pattern recognition molecules, but also complement regulation via recruitment of complement regulators. The encoded protein has a calcium dependent ligand binding domain with a distinctive flattened beta-jellyroll structure. It exists in two forms as either a pentamer in circulation or as a nonsoluble monomer in tissues. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. [provided by RefSeq, Aug 2020]

Canonical amino-acid sequenceUniProt

224 residues, UniProt reviewed canonical sequence.

>P02741|CRP
     1  MEKLLCFLVL TSLSHAFGQT DMSRKAFVFP KESDTSYVSL KAPLTKPLKA FTVCLHFYTE
    61  LSSTRGYSIF SYATKRQDNE ILIFWSKDIG YSFTVGGSEI LFEVPEVTVA PVHICTSWES
   121  ASGIVEFWVD GKPRVRKSLK KGYTVGAEAS IILGQEQDSF GGNFEGSQSL VGDIGNVNMW
   181  DFVLSPDEIN TIYLGGPFSP NVLNWRALKY EVQGEVFTKP QLWP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

8,525 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CRP.

Disease | ImmuneIEDB

Conditions an epitope on CRP was assayed in.

• autoimmune glomerulonephritis B cell

Disease | AutoantibodyPubMed

Conditions in which antibodies against CRP are reported. Each links to that disease's full target list.

• Lupus Erythematosus, Systemic 15
• Lupus Nephritis 9
• Arthritis, Rheumatoid 4
• Uveitis 3

Showing 4 of 5 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for CRP from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.92

gnomAD pLI

0

gnomAD missense Z

-0.25

DepMap mean gene effect

-0.07

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• acute-phase response
• defense response to Gram-positive bacterium
• inflammatory response
• innate immune response
• negative regulation of lipid storage
• negative regulation of macrophage derived foam cell differentiation
• negative regulation of mononuclear cell proliferation
• opsonization
• positive regulation of gene expression
• positive regulation of superoxide anion generation
• regulation of interleukin-8 production
• vasoconstriction

Molecular functions

• calcium ion binding
• choline binding
• complement component C1q complex binding
• identical protein binding
• low-density lipoprotein particle binding
• low-density lipoprotein particle receptor binding

Cellular components

• extracellular region
• extracellular space

Protein domainsUniProt · Pfam · InterPro

• Pentraxin domain
• Concanavalin A-like lectin/glucanase domain superfamily
• Pentaxin, conserved site
• Pentraxin domain-containing protein
• Pentaxin family

KeywordsUniProt

• Acute phase
• Calcium
• Disulfide bond
• Metal-binding
• Pyrrolidone carboxylic acid
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of CRP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FCN1