PTX3

Protein identityUniProt · HPA

UniProt accession

P26022

Gene

PTX3

Ensembl

ENSG00000163661

Chromosome

3

Canonical length

381 aa

Protein class

Plasma proteins, Predicted secreted proteins

Subcellular location

Plasma membrane

Secretome location

Secreted to blood

Quaternary structure

Homooctamer

OverviewNCBI Gene

This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. [provided by RefSeq, Jun 2016]

Canonical amino-acid sequenceUniProt

381 residues, UniProt reviewed canonical sequence.

>P26022|PTX3
     1  MHLLAILFCA LWSAVLAENS DDYDLMYVNL DNEIDNGLHP TEDPTPCACG QEHSEWDKLF
    61  IMLENSQMRE RMLLQATDDV LRGELQRLRE ELGRLAESLA RPCAPGAPAE ARLTSALDEL
   121  LQATRDAGRR LARMEGAEAQ RPEEAGRALA AVLEELRQTR ADLHAVQGWA ARSWLPAGCE
   181  TAILFPMRSK KIFGSVHPVR PMRLESFSAC IWVKATDVLN KTILFSYGTK RNPYEIQLYL
   241  SYQSIVFVVG GEENKLVAEA MVSLGRWTHL CGTWNSEEGL TSLWVNGELA ATTVEMATGH
   301  IVPEGGILQI GQEKNGCCVG GGFDETLAFS GRLTGFNIWD SVLSNEEIRE TGGAESCHIR
   361  GNIVGWGVTE IQPHGGAQYV S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTX3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.35

Highest tissue expression

230 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PTX3.

Disease | ImmuneIEDB

Conditions an epitope on PTX3 was assayed in.

• systemic lupus erythematosus B cell

Disease | AutoantibodyPubMed

Conditions in which antibodies against PTX3 are reported. Each links to that disease's full target list.

• Lupus Erythematosus, Systemic 6
• Lupus Nephritis 6
• Proteinuria 3

ReferencesPubMed · IEDB

Publications for PTX3 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.2

gnomAD pLI

0

gnomAD missense Z

-0.05

DepMap mean gene effect

0.08

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• extracellular matrix organization
• host-mediated suppression of symbiont invasion
• host-mediated suppression of viral proces
• inflammatory response
• innate immune response
• negative regulation by host of viral glycoprotein metabolic process
• negative regulation of glycoprotein metabolic process
• opsonization
• ovarian cumulus expansion
• positive regulation of nitric oxide biosynthetic process
• positive regulation of phagocytosis
• response to yeast

Molecular functions

• (1->3)-beta-D-glucan binding
• complement component C1q complex binding
• identical protein binding
• virion binding

Cellular components

• extracellular matrix
• extracellular region
• extracellular space
• specific granule lumen
• tertiary granule lumen

Protein domainsUniProt · Pfam · InterPro

• Pentraxin domain
• LamG-like jellyroll fold
• Concanavalin A-like lectin/glucanase domain superfamily
• Pentaxin, conserved site
• Pentaxin family
• Pentraxin-related protein PTX3
• PTX3-like, N-terminal domain
• PTX3-like, N-terminal domain

KeywordsUniProt

• Coiled coil
• Disulfide bond
• Glycoprotein
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of PTX3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FGF2