APCS

Protein identityUniProt · HPA

UniProt accession

P02743

Gene

APCS

Ensembl

ENSG00000132703

Chromosome

1

Canonical length

223 aa

Protein class

Disease related genes, Plasma proteins, Potential drug targets, Predicted secreted proteins, Transporters

Secretome location

Secreted to blood

Quaternary structure

Homopentamer

OverviewNCBI Gene

The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. [provided by RefSeq, Sep 2008]

Canonical amino-acid sequenceUniProt

223 residues, UniProt reviewed canonical sequence.

>P02743|APCS
     1  MNKPLLWISV LTSLLEAFAH TDLSGKVFVF PRESVTDHVN LITPLEKPLQ NFTLCFRAYS
    61  DLSRAYSLFS YNTQGRDNEL LVYKERVGEY SLYIGRHKVT SKVIEKFPAP VHICVSWESS
   121  SGIAEFWING TPLVKKGLRQ GYFVEAQPKI VLGQEQDSYG GKFDRSQSFV GEIGDLYMWD
   181  SVLPPENILS AYQGTPLPAN ILDWQALNYE IRGYVIIKPL VWV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APCS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

3,389 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.83

gnomAD pLI

0.03

gnomAD missense Z

-0.23

DepMap mean gene effect

-0.09

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• acute-phase response
• chaperone-mediated protein complex assembly
• host-mediated suppression of symbiont invasion
• innate immune response
• negative regulation by host of viral glycoprotein metabolic process
• negative regulation of acute inflammatory response
• negative regulation of glycoprotein metabolic process
• negative regulation of monocyte differentiation
• negative regulation of viral process
• negative regulation of wound healing
• protein folding

Molecular functions

• calcium ion binding
• carbohydrate binding
• complement component C1q complex binding
• identical protein binding
• unfolded protein binding
• virion binding

Cellular components

• blood microparticle
• extracellular exosome
• extracellular region
• extracellular space
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Pentraxin domain
• Concanavalin A-like lectin/glucanase domain superfamily
• Pentaxin, conserved site
• Pentraxin domain-containing protein
• Pentaxin family

KeywordsUniProt

• Amyloid
• Calcium
• Disulfide bond
• Glycoprotein
• Lectin
• Metal-binding
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of APCS in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FCGR2A