Seroatlas · Human Serome Atlas

WASH6P

WAS protein family homolog 6

Also known as: WASH6_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NQA3
Gene
WASH6P
Canonical length
447 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for WASH6P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

447 residues, UniProt reviewed canonical sequence.

>Q9NQA3|WASH6P
     1  MAFHEMQAHK NALGTSGEQQ AADITGPTPH QGGWKQVEQS RSQVQAIGEK VSLAQAKIEK
    61  IKGSKKAIKV FSSAKYPAPE RLQEYGSIFT GAQDPGLQRR PRHRIQSKHR PLDERALQEK
   121  LKDFPVCVST KPEPEDDAEE GLGGLPSNIS SVSSLLLFNT TENLYKKYVF LDPLAGAVTK
   181  THVMLGAETE EKLFDAPLSI SKREQLEQQV PENYFYVPDL GQVPEIDVPS YLPDLPSIAN
   241  DLMYSADLGP GIAPSAPGTI PELPTFHTEV AEPLKADLQD GVLTPPPPPP PPPPAPEVLA
   301  SAPPLPPSTA APVGQGARQD DGSSSASPSV QGAPREVVDP SGGWATLLES IRQAGGIGKA
   361  KLRSMKERKL EKKKQKEQEQ VRATSQGGHL MSDLFNKLVM RRKGISGKGP GAGEGPGGAF
   421  ARVSDSIPPV PPPQQPQAEE DEDDWES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WASH6P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
8.9 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 8.9 nTPM
  • cerebellum: 5 nTPM
  • skin: 4 nTPM
  • kidney: 3.9 nTPM
  • testis: 3.8 nTPM
  • heart muscle: 3.5 nTPM

Single-cell type

  • mast cells: 83 nCPM
  • megakaryocyte-erythroid progenitors: 75 nCPM
  • hematopoietic stem cells: 73 nCPM
  • megakaryocyte progenitors: 45 nCPM
  • kupffer cells: 40 nCPM
  • urothelial cells: 38 nCPM

Immune cell

  • NK-cell: 0.6 nTPM
  • non-classical monocyte: 0.6 nTPM
  • T-reg: 0.3 nTPM
  • total PBMC: 0.3 nTPM
  • memory B-cell: 0.2 nTPM
  • plasmacytoid DC: 0.2 nTPM

Brain region

  • white matter: 4.4 nTPM
  • cerebral cortex: 3.8 nTPM
  • medulla oblongata: 3.5 nTPM
  • midbrain: 3.3 nTPM
  • cerebellum: 3.2 nTPM
  • pons: 3.2 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WASH6P as an antibody target. Whether an autoantibody or antibody against WASH6P could matter depends on whether native WASH6P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WASH6P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WASH6P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WASH6P. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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