Seroatlas · Human Serome Atlas

WASH4P

Putative WAS protein family homolog 4

Also known as: WASH4_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MWX3
Gene: WASH4P
Canonical length: 477 aa

OverviewNCBI Gene

No narrative summary is available for WASH4P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

477 residues, UniProt reviewed canonical sequence.

>A8MWX3|WASH4P
     1  MSGVMCLKAS DTWASGIRSQ PQGCLGKWRS MRCKHTRMHL AHLGNSRQLI SLGPPRTRED
    61  GSRISQQVEQ SRSQVQAIGE KVSLAQAKIE KIKGSKKAIK VFSSAKYPAP ERLQEYGSIF
   121  TDAQDPGLQR RPRHRIQSKQ RPLDERALQE KLKDFPVCVS TKPEPEDDAE EGLGGLPSNI
   181  SSVSSLLLFN TTENLYKKYV FLDPLAGAVT KTHVMLGAET EEKLFDAPLS ISKREQLEQQ
   241  VPENYFYVPD LGQVPEIDVP SYLPDLPGIA NDLMYIADLG PGIAPSAPGT IPELPTFHTE
   301  VAEPLKVDLQ DGVLTPPPPP PPPPPAPEVL ASAPPLPPST AAPVGQGARQ DDSSSSASPS
   361  VQGAPREVVD PSGGWATLLE SIRQAGGIGK AKLRSMKERK LEKQQQKEQE QVRATSQGGH
   421  LMSDLFNKLV MRRKGISGKG PGAGDGPGGA FARVSDSIPP LPPPQQPQAE DEDDWES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WASH4P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0
gnomAD missense Z: -0.34

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WASH4P as an antibody target. Whether an autoantibody or antibody against WASH4P could matter depends on whether native WASH4P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WASH4P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WASH4P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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