Insulin/IGF/relaxin

Definition

The insulin/IGF/relaxin superfamily is an ancient family of functionally diverse proteins PMID:6107857. The 3D structures of a number of family members have been determined [[cite:PMID:2036417], [cite:PMID:1319992], [cite:PMID:9141131]]. The fold comprises two polypeptide chains (A and B) linked by two disulphide bonds: all share a conserved arrangement of four cysteines in their A chain, the first of which is linked by a disulfide bond to the third, while the second and fourth are linked by interchain disulfide bonds to cysteines in the B chain. This family includes: Insulin and insulin-like proteins [[cite:PMID:6243748], [cite:PMID:503234]] Relaxin [[cite:PMID:10601981], [cite:PMID:8735594]] and prorelaxin Insect prothoracicotropic hormone (bombyxin) PMID:8683595 Insulin-like growth factors (IGF1 and IGF2) [[cite:PMID:2036417], [cite:PMID:1319992]] Mammalian Leydig cell-specific insulin-like peptide (gene INSL3) Invertebrates insulin-related peptides (IRPs) PMID:30747102

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• IGF1
• IGF2
• RLN1
• RLN2
• RLN3