Seroatlas · Human Serome Atlas

RLN2

Prorelaxin H2

Also known as: bA12D24.1.1, bA12D24.1.2, H2, REL2_HUMAN, RLXH2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P04090
Gene: RLN2
Ensembl: ENSG00000107014
Chromosome: 9
Canonical length: 185 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the relaxin subfamily and insulin superfamily of peptide hormones. In humans there are three non-allelic relaxin genes. This gene encodes multiple protein isoforms, at least one of which undergoes proteolytic processing. This processing generates relaxin A and B chains that are linked by disulfide bonds to form the mature peptide hormone. This hormone plays a role in the male and female reproductive systems and was initially noted for its role in pregnancy. This protein also plays broader roles in the cardiovascular system, including in the regulation of blood pressure and control of heart rate, and data from animal models shows that this protein may have anti-fibrotic and cardioprotective effects. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

185 residues, UniProt reviewed canonical sequence.

>P04090|RLN2
     1  MPRLFFFHLL GVCLLLNQFS RAVADSWMEE VIKLCGRELV RAQIAICGMS TWSKRSLSQE
    61  DAPQTPRPVA EIVPSFINKD TETINMMSEF VANLPQELKL TLSEMQPALP QLQQHVPVLK
   121  DSSLLFEEFK KLIRNRQSEA ADSSPSELKY LGLDTHSRKK RQLYSALANK CCHVGCTKRS
   181  LARFC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RLN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 4.8 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 4.8 nTPM
parathyroid gland: 4 nTPM
prostate: 3.7 nTPM
pituitary gland: 2.8 nTPM
retina: 2.7 nTPM
lymph node: 2.6 nTPM

Single-cell type

oocytes: 60 nCPM
late primary spermatocytes: 30 nCPM
epididymal efferent duct ciliated cells: 17 nCPM
syncytiotrophoblasts: 16 nCPM
megakaryocytes: 12 nCPM
fallopian tube ciliated cells: 9.3 nCPM

Immune cell

MAIT T-cell: 4.2 nTPM
naive CD4 T-cell: 4 nTPM
NK-cell: 3.5 nTPM
naive CD8 T-cell: 3 nTPM
memory CD4 T-cell: 2.8 nTPM
memory CD8 T-cell: 2.3 nTPM

Brain region

cerebellum: 0.6 nTPM
pons: 0.6 nTPM
cerebral cortex: 0.5 nTPM
choroid plexus: 0.5 nTPM
hypothalamus: 0.5 nTPM
medulla oblongata: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: -1.32
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

hormone activity

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RLN2 as an antibody target. Whether an autoantibody or antibody against RLN2 could matter depends on whether native RLN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RLN2 is annotated as secreted, so native RLN2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label RLN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...