Seroatlas · Human Serome Atlas

RLN3

Relaxin-3

Also known as: H3, REL3_HUMAN, RXN3, ZINS4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WXF3
Gene: RLN3
Ensembl: ENSG00000171136
Chromosome: 19
Canonical length: 142 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the relaxin family of insulin-like hormones that is expressed predominantly in the brain and plays a role in physiological processes such as stress, memory and appetite regulation. The encoded protein is a precursor that is proteolytically processed to generate a heterodimeric mature form consisting A and B chains interlinked by disulfide bonds. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]

Canonical amino-acid sequenceUniProt

142 residues, UniProt reviewed canonical sequence.

>Q8WXF3|RLN3
     1  MARYMLLLLL AVWVLTGELW PGAEARAAPY GVRLCGREFI RAVIFTCGGS RWRRSDILAH
    61  EAMGDTFPDA DADEDSLAGE LDEAMGSSEW LALTKSPQAF YRGRPSWQGT PGVLRGSRDV
   121  LAGLSSSCCK WGCSKSEISS LC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RLN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 2.6 nTPM

Expression across tissuesHPA

Tissue

testis: 2.6 nTPM
parathyroid gland: 1.5 nTPM
prostate: 0.6 nTPM
spleen: 0.6 nTPM
lung: 0.3 nTPM
midbrain: 0.3 nTPM

Single-cell type

brain inhibitory neurons: 0.7 nCPM
other brain neurons: 0.2 nCPM
ependymal cells: 0.1 nCPM
microglia: 0.1 nCPM
oligodendrocyte progenitor cells: 0.1 nCPM
adipocytes: 0 nCPM

Immune cell

naive B-cell: 0.5 nTPM
T-reg: 0.3 nTPM
myeloid DC: 0.2 nTPM
naive CD4 T-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM
MAIT T-cell: 0.1 nTPM

Brain region

pons: 0.4 nTPM
midbrain: 0.3 nTPM
thalamus: 0.2 nTPM
cerebellum: 0.1 nTPM
choroid plexus: 0.1 nTPM
hypothalamus: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.66
gnomAD pLI: 0.01
gnomAD missense Z: -0.16
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RLN3 as an antibody target. Whether an autoantibody or antibody against RLN3 could matter depends on whether native RLN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RLN3 is annotated as secreted, so native RLN3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label RLN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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