Chemokine-like protein TAFA

Definition

This family is composed of five highly homologous small secreted proteins, TAFA1-5. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The FAM19/TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells PMID:15028294. Mouse TAFA2 is involved in neuronal survival and neurobiological functions PMID:30137205. TAFA5 has been shown to inhibit postinjury neointima formation via sphingosine-1-phosphate receptor 2-G12/13-RhoA signaling PMID:29453251.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• TAFA1
• TAFA2
• TAFA3
• TAFA4
• TAFA5