Seroatlas · Human Serome Atlas

TAFA1

Chemokine-like protein TAFA-1

Also known as: FAM19A1, TAFA-1, TAFA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z5A9
Gene: TAFA1
Ensembl: ENSG00000183662
Chromosome: 3
Canonical length: 133 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in brain

OverviewNCBI Gene

This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

133 residues, UniProt reviewed canonical sequence.

>Q7Z5A9|TAFA1
     1  MAMVSAMSWV LYLWISACAM LLCHGSLQHT FQQHHLHRPE GGTCEVIAAH RCCNKNRIEE
    61  RSQTVKCSCL PGKVAGTTRN RPSCVDASIV IGKWWCEMEP CLEGEECKTL PDNSGWMCAT
   121  GNKIKTTRIH PRT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAFA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 18 nTPM
hippocampal formation: 12 nTPM
choroid plexus: 6.8 nTPM
amygdala: 6.6 nTPM
hypothalamus: 3.5 nTPM
seminal vesicle: 3.4 nTPM

Single-cell type

brain excitatory neurons: 933 nCPM
oligodendrocyte progenitor cells: 561 nCPM
adrenal medulla cells: 330 nCPM
other brain neurons: 162 nCPM
astrocytes: 137 nCPM
brain inhibitory neurons: 109 nCPM

Immune cell

gdT-cell: 7.6 nTPM
memory CD4 T-cell: 5.6 nTPM
naive CD8 T-cell: 5.4 nTPM
MAIT T-cell: 4.8 nTPM
memory CD8 T-cell: 4.4 nTPM
naive CD4 T-cell: 4.1 nTPM

Brain region

hippocampal formation: 27 nTPM
pons: 27 nTPM
cerebral cortex: 22 nTPM
basal ganglia: 17 nTPM
hypothalamus: 17 nTPM
white matter: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0.33
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

receptor ligand activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAFA1 as an antibody target. Whether an autoantibody or antibody against TAFA1 could matter depends on whether native TAFA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAFA1 is annotated as secreted, so native TAFA1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label TAFA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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