Seroatlas · Human Serome Atlas

TAFA4

Chemokine-like protein TAFA-4

Also known as: FAM19A4, TAFA-4, TAFA4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96LR4
Gene: TAFA4
Ensembl: ENSG00000163377
Chromosome: 3
Canonical length: 140 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted in brain

OverviewNCBI Gene

This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

140 residues, UniProt reviewed canonical sequence.

>Q96LR4|TAFA4
     1  MRSPRMRVCA KSVLLSHWLF LAYVLMVCCK LMSASSQHLR GHAGHHQIKQ GTCEVVAVHR
    61  CCNKNRIEER SQTVKCSCFP GQVAGTTRAQ PSCVEASIVI QKWWCHMNPC LEGEDCKVLP
   121  DYSGWSCSSG NKVKTTKVTR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAFA4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 14 nTPM
retina: 10 nTPM
spinal cord: 6.9 nTPM
stomach: 4.6 nTPM
midbrain: 2.5 nTPM
hypothalamus: 2.4 nTPM

Single-cell type

cone photoreceptor cells: 511 nCPM
retinal bipolar cells: 389 nCPM
retinal amacrine cells: 92 nCPM
oocytes: 83 nCPM
retinal horizontal cells: 70 nCPM
oligodendrocytes: 64 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 24 nTPM
midbrain: 20 nTPM
hypothalamus: 17 nTPM
white matter: 15 nTPM
basal ganglia: 11 nTPM
amygdala: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

receptor ligand activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAFA4 as an antibody target. Whether an autoantibody or antibody against TAFA4 could matter depends on whether native TAFA4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAFA4 is annotated as secreted, so native TAFA4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label TAFA4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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