Seroatlas · Human Serome Atlas

TAFA5

Chemokine-like protein TAFA-5

Also known as: FAM19A5, TAFA-5, TAFA5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z5A7
Gene: TAFA5
Ensembl: ENSG00000219438
Chromosome: 22
Canonical length: 132 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted in brain

OverviewNCBI Gene

This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Sep 2013]

Canonical amino-acid sequenceUniProt

132 residues, UniProt reviewed canonical sequence.

>Q7Z5A7|TAFA5
     1  MAPSPRTGSR QDATALPSMS STFWAFMILA SLLIAYCSQL AAGTCEIVTL DRDSSQPRRT
    61  IARQTARCAC RKGQIAGTTR ARPACVDARI IKTKQWCDML PCLEGEGCDL LINRSGWTCT
   121  QPGGRIKTTT VS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAFA5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 78 nTPM

Expression across tissuesHPA

Tissue

hippocampal formation: 78 nTPM
amygdala: 71 nTPM
hypothalamus: 69 nTPM
cerebral cortex: 69 nTPM
basal ganglia: 57 nTPM
midbrain: 56 nTPM

Single-cell type

astrocytes: 195 nCPM
retinal amacrine cells: 168 nCPM
brain excitatory neurons: 161 nCPM
retinal ganglion cells: 155 nCPM
oligodendrocyte progenitor cells: 145 nCPM
schwann cells: 143 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 201 nTPM
medulla oblongata: 132 nTPM
hippocampal formation: 128 nTPM
pons: 123 nTPM
thalamus: 121 nTPM
amygdala: 119 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0.45
DepMap mean gene effect: 0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Chemokine-like protein TAFA
TAFA family
Chemokine-like protein TAFA-5

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAFA5 as an antibody target. Whether an autoantibody or antibody against TAFA5 could matter depends on whether native TAFA5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAFA5 is annotated as secreted, so native TAFA5 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label TAFA5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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