Seroatlas · Human Serome Atlas

TAFA3

Chemokine-like protein TAFA-3

Also known as: FAM19A3, TAFA-3, TAFA3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z5A8
Gene: TAFA3
Ensembl: ENSG00000184599
Chromosome: 1
Canonical length: 133 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

133 residues, UniProt reviewed canonical sequence.

>Q7Z5A8|TAFA3
     1  MSERVERNWS TGGWLLALCL AWLWTHLTLA ALQPPTATVL VQQGTCEVIA AHRCCNRNRI
    61  EERSQTVKCS CFSGQVAGTT RAKPSCVDAS IVLQRWWCQM EPCLPGEECK VLPDLSGWSC
   121  SSGHKVKTTK VTR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAFA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

retina: 43 nTPM
adrenal gland: 13 nTPM
testis: 7.1 nTPM
cerebellum: 3.4 nTPM
midbrain: 2.3 nTPM
spinal cord: 1 nTPM

Single-cell type

cone photoreceptor cells: 106 nCPM
retinal bipolar cells: 49 nCPM
adrenal medulla cells: 32 nCPM
retinal pigment epithelial cells: 30 nCPM
late spermatids: 26 nCPM
late primary spermatocytes: 23 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 6.1 nTPM
thalamus: 5.6 nTPM
medulla oblongata: 4.1 nTPM
amygdala: 2.6 nTPM
cerebellum: 2.5 nTPM
pons: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.66
gnomAD pLI: 0
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

receptor ligand activity

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAFA3 as an antibody target. Whether an autoantibody or antibody against TAFA3 could matter depends on whether native TAFA3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAFA3 is annotated as secreted, so native TAFA3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label TAFA3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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